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PHR1565

Supelco

D4 Cyclomethicone

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Octamethylcyclotetrasiloxane
Linear Formula:
[-Si(CH3)2O-]4
CAS Number:
556-67-2
Molecular Weight:
296.62
Beilstein:
1787074
EC Number:
209-136-7
MDL number:
MFCD00003269
UNSPSC Code:
41116107
PubChem Substance ID:
329823474
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1154707

vapor density

1 (vs air)

API family

cyclomethicone

form

liquid

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.396 (lit.)

bp

175-176 °C (lit.)

mp

17-18 °C (lit.)

density

0.956 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1

InChI

1S/C8H24O4Si4/c1-13(2)9-14(3,4)11-16(7,8)12-15(5,6)10-13/h1-8H3

InChI key

HMMGMWAXVFQUOA-UHFFFAOYSA-N

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General description

D4 Cyclomethicone is a cyclic siloxane, that has a silicon-oxygen bond in a cyclic arrangement and methyl groups attached with the silicon atom. It is used in the production of some silicon-based polymers that are widely used in various personal care products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

D4 Cyclomethicone may be used as a pharmaceutical reference standard for the determination of the analyte in personal care formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2961 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signal Word

Warning

Hazard Statements

H226,H361f,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Flam. Liq. 3 - Repr. 2

WGK

WGK 3

Flash Point(F)

123.8 °F

Flash Point(C)

51 °C

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane
Johnson Jr, et al.
International Journal of Toxicology, 30, 149S-227S (2011)
Sensitive method for quantification of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air by thermal desorption gas chromatography mass spectrometry
Biesterbos JWH, et al.
Analytical Chemistry, 86(12), 5794-5799 (2014)
Determination of cyclic volatile methylsiloxanes in personal care products by gas chromatography
Brothers Jr HM, et al.
International Journal of Cosmetic Science, 39(6), 580-588 (2017)

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