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PHR1545

Chlorobutanol

Name: Chlorobutanol
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate, β,β,β-Trichloro-tert-butyl alcohol hemihydrate, ‘Acetone chloroform’, ‘Chlorobutanol’

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About This Item

Linear Formula:

Cl₃CC(CH₃)₂OH · 0.5H₂O

CAS Number:

6001-64-5

Molecular Weight:

186.46

Beilstein:

878167

EC Number:

249-042-3

MDL number:

MFCD02179352

UNSPSC Code:

41116107

PubChem Substance ID:

329823454

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1112503

API family

chlorobutanol

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O.CC(C)(O)C(Cl)(Cl)Cl.CC(C)(O)C(Cl)(Cl)Cl

InChI

1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2

InChI key

WRWLCXJYIMRJIN-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorobutanol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and ophthalmic ointments by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7819 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

212.0 °F

Flash Point(C)

100 °C

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Determination of chlorobutanol in pharmaceuticals by gas chromatography.

Koshy KT, et al.

Journal of Pharmaceutical Sciences, 56(2), 269-271 (1967)

Analysis of potential genotoxic impurities in pharmaceuticals by two-dimensional gas chromatography with Deans switching and independent column temperature control using a low-thermal-mass oven module.

David F, et al.

Analytical and Bioanalytical Chemistry, 396(3), 1291-1300 (2010)

Analysis of Chlorobutanol in Ophthalmie Ointments and Aqueous Solutions by Reverse-Phase High-Performance Liquid Chromatography.

Dunn DL, et al.

Journal of Pharmaceutical Sciences, 72(3), 277-280 (1983)

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