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PHR1542

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Moxifloxacin Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Moxifloxacin hydrochloride, 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
Empirical Formula (Hill Notation):
C21H24FN3O4· HCl
CAS Number:
186826-86-8
Molecular Weight:
437.89
Beilstein:
8377447
MDL number:
MFCD00949117
UNSPSC Code:
41116107
PubChem Substance ID:
329823452
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0000703
traceable to USP 1448606

API family

moxifloxacin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(O)=O

InChI

1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1

InChI key

IDIIJJHBXUESQI-DFIJPDEKSA-N

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General description

Moxifloxacin Hydrochloride is an anti-infectious compound that belongs to the class of fluoroquinolone antibiotics. It is a well-known broad-spectrum antibiotic prescription medicine effective against a variety of Gram-positive and Gram-negative bacteria including the anaerobic type. It is an S,S-isomer with two chiral centers. It works by preventing the activity of various crucial enzymes involved in the replication, transcription, recombination, and repair of deoxyribonucleic acid in the bacteria such as DNA gyrase (topoisomerase II), topoisomerase IV. It finds its application in the treatment of various ocular and respiratory tract infections.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

Moxifloxacin Hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by spectrophotometric, chromatographic, and electrochemical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0258 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

Y0000703

Moxifloxacin hydrochloride, European Pharmacopoeia (EP) Reference Standard

1448606

Moxifloxacin hydrochloride, United States Pharmacopeia (USP) Reference Standard

1448617

Moxifloxacin Related Compound A, United States Pharmacopeia (USP) Reference Standard

1448640

Moxifloxacin Related Compound D, United States Pharmacopeia (USP) Reference Standard

1448639

Moxifloxacin Related Compound C, United States Pharmacopeia (USP) Reference Standard

1448628

Moxifloxacin Related Compound B, United States Pharmacopeia (USP) Reference Standard

1448655

Moxifloxacin Related Compound E, United States Pharmacopeia (USP) Reference Standard

1448672

Moxifloxacin Related Compound G, United States Pharmacopeia (USP) Reference Standard

1448661

Moxifloxacin Related Compound F, United States Pharmacopeia (USP) Reference Standard

Y0002099

Moxifloxacin for peak identification A, European Pharmacopoeia (EP) Reference Standard

Y0002078

Moxifloxacin for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0002081

Moxifloxacin for peak identification B, European Pharmacopoeia (EP) Reference Standard

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and validation of UV-spectrophotometric methods for determination of moxifloxacin HCl in bulk and pharmaceutical formulations
Tarkase KN, et al.
Der Pharma Chemica, 4(3), 1180-1185 (2012)
Electrochemical determination of antibacterial drug moxifloxacin hydrochloride using chloranil modified carbon paste electrode
Attia AK and El-Shal MA
Analytical and Bioanalytical Chemistry, 4(3), 213-224 (2012)
Validated spectrophotometric methods for the estimation of moxifloxacin in bulk and pharmaceutical formulations
Motwani SK, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 68(2), 250-256 (2007)
Enantiomeric purity assay of moxifloxacin hydrochloride by capillary electrophoresis
Cruz LA and Hall R
Journal of Pharmaceutical and Biomedical Analysis, 38(1), 8-13 (2005)
Development and validation of spectrophotometric, atomic absorption and kinetic methods for determination of moxifloxacin hydrochloride
Abdellaziz LM and Hosny MM
Analytical Chemistry Insights, 6(3), ACI-S8090 (2011)
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