PHR1530
Acetaminophen Related Compound D
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Acetanilide, N-Phenylacetamide
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About This Item
Linear Formula:
CH3CONHC6H5
CAS Number:
Molecular Weight:
135.16
Beilstein:
606468
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to USP 1003042
vapor density
4.65 (vs air)
vapor pressure
1 mmHg ( 114 °C)
description
API family: acetaminophen
API family
acetaminophen, paracetamol
CofA
current certificate can be downloaded
autoignition temp.
1004 °F
packaging
pkg of 200 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
bp
304 °C (lit.)
mp
113-115 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
CC(=O)Nc1ccccc1
InChI
1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
InChI key
FZERHIULMFGESH-UHFFFAOYSA-N
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General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antipyretic and analgesic drug acetaminophen, also known as paracetamol.
Application
This pharmaceutical secondary standard can also be used as follows:
- Detection and quantification of paracetamol, phenylephrine hydrochloride, and paracetamol impurities in pharmaceutical formulations using four chemometric-based spectrophotometric methods
- Simultaneous determination of paracetamol and phenylephrine hydrochloride in the presence of paracetamol-related impurities using capillary zone electrophoresis (CZE) in their combined tablet forms
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAA3648 in the slot below. This is an example certificate only and may not be the lot that you receive.
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Product No.
Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 1
Flash Point(F)
321.8 °F
Flash Point(C)
161 °C
Regulatory Information
危险化学品
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Capillary zone electrophoresis as a quality assessment tool of paracetamol and phenylephrine hydrochloride in presence of paracetamol impurities
FARID J, et al.
Turkish Journal of Chemistry, 46, 217-223 (2022)
Octavian Călinescu et al.
Journal of chromatographic science, 50(4), 335-342 (2012-03-13)
Determination of acetaminophen and its main impurities: 4-nitrophenol, 4'-chloroacetanilide, as well as 4-aminophenol and its degradation products, p-benzoquinone and hydroquinone has been developed and validated by a new high-performance liquid chromatography method. Chromatographic separation has been obtained on a Hypersil
Fabrice Gritti et al.
Journal of chromatography. A, 1355, 179-192 (2014-07-09)
The mass transfer mechanism in four prototype columns (2.1 and 3.0×50mm, 2.1 and 3.0×100mm) packed with 1.9μm fully porous Titan-C18 particles was investigated by using two previously reported home-made protocols. The first one was used to measure the eddy dispersion
Naoki Aizawa et al.
Neurourology and urodynamics, 34(4), 368-374 (2014-02-18)
We measured single-unit mechanosensitive afferent activities (SAAs) during reflexic, rhythmic bladder contractions (RBCs), and examined whether L-arginine, an NO substrate, and mirabegron, a β3-adrenoceptor agonist, and oxybutynin, an antimuscarinic agent, can affect the SAAs in such condition. Twenty-nine female Sprague-Dawley
Hassan A Alhazmi et al.
Journal of pharmaceutical and biomedical analysis, 107, 311-317 (2015-02-02)
In this work, the behavior of several metal ions with different globular proteins was investigated by affinity capillary electrophoresis. Screening was conducted by applying a proper rinsing protocol developed by our group. The use of 0.1M EDTA in the rinsing
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