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PHR1528

Oxaliplatin

Name: Oxaliplatin
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Oxaliplatin, [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₄N₂O₄Pt

CAS Number:

61825-94-3

Molecular Weight:

397.29

MDL number:

MFCD00866327

UNSPSC Code:

41116107

PubChem Substance ID:

329823440

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0000271
traceable to USP 1481204

API family

oxaliplatin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N

InChI

1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1

InChI key

ZROHGHOFXNOHSO-BNTLRKBRSA-L

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Oxaliplatin, a third generation anti-cancer drug platinum compound, is utilized for the treatment of colorectal cancer. It exhibits a better safety profile than cisplatin (first generation) and carboplatin (second generation).

Application

Oxaliplatin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and electrophoresis techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB8974 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

1481226

1481215

1481237

1481248

1481306

Oxaliplatin System Suitability, United States Pharmacopeia (USP) Reference Standard

1481260

PHR2545

Pictograms

GHS08,GHS05

Signal Word

Danger

Hazard Statements

H317,H318,H334,H341,H351,H360FD,H362,H372

Precautionary Statements

P260 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Investigation of a liposomal oxaliplatin drug formulation by capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry (CE-ICP-MS).

Nguyen TTTN, et al.

Analytical and Bioanalytical Chemistry, 402(6), 2131-2139 (2012)

Quality control of pharmaceutical formulations containing cisplatin, carboplatin, and oxaliplatin by micellar and microemulsion electrokinetic chromatography (MEKC, MEEKC).

Nussbaumer S, et al.

Journal of Pharmaceutical and Biomedical Analysis, 55(2), 253-258 (2011)

Characterization of a liposome-based formulation of oxaliplatin using capillary electrophoresis: encapsulation and leakage.

Franzen U, et al.

Journal of Pharmaceutical and Biomedical Analysis, 55(1), 16-22 (2011)

Validation of a LC method for the analysis of oxaliplatin in a pharmaceutical formulation using an experimental design.

Ficarra R, et al.

Journal of Pharmaceutical and Biomedical Analysis, 29(6), 1097-1103 (2002)

Isolated hepatic perfusion with oxaliplatin combined with 100 mg melphalan in patients with metastases confined to the liver: A phase I study.

L B J van Iersel et al.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(11), 1557-1563 (2014-08-16)

To improve isolated hepatic perfusion (IHP), we performed a phase I dose-escalation study to determine the optimal oxaliplatin dose in combination with a fixed melphalan dose. Between June 2007 and July 2008, 11 patients, comprising of 8 colorectal cancer and

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