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PHR1524

Tamsulosin hydrochloride

Name: Tamsulosin hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Tamsulosin hydrochloride, (−)-(R)-5-[2-[[2-(o-ethoxy phenoxy)ethyl]amino]propyl]-2-methoxy benzene sulfonamide, monohydrochloride, TAM, 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₈N₂O₅S · HCl

CAS Number:

106463-17-6

Molecular Weight:

444.97

MDL number:

MFCD00922997

UNSPSC Code:

41116107

PubChem Substance ID:

329823437

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 876
traceable to Ph. Eur. Y0000650
traceable to USP 1643260

API family

tamsulosin

CofA

current certificate can be downloaded

packaging

ampule of 1 × 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O

InChI

1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

InChI key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Tamsulosin hydrochloride is a subtypeselective a₁A and a₁D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

Application

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Development and validation of stability-indicating HPTLC determination of tamsulosin in bulk and pharmaceutical dosage form

Bari.BS, et al.

Chromatography Research International, 2011(2), 197-205 (2011)

Validated RP-HPLC and TLC methods for simultaneous estimation of tamsulosin hydrochloride and finasteride in combined dosage forms

Patel B.D and Patel J.N

Acta pharmaceutica, 60(2), 197-205 (2010)

Validated stability indicating HPTLC method for the determination of Tamsulosin hydrochloride in pharmaceutical dosage forms

Choudhari.PV and Nikalje GPA

International Journal of ChemTech Research, 2(1), 646-652 (2010)

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