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Key Documents

PHR1524

Supelco

Tamsulosin hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Tamsulosin hydrochloride, (−)-(R)-5-[2-[[2-(o-ethoxy phenoxy)ethyl]amino]propyl]-2-methoxy benzene sulfonamide, monohydrochloride, TAM, 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

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200 MG
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200 MG
¥3,367.57

About This Item

Empirical Formula (Hill Notation):
C20H28N2O5S · HCl
CAS Number:
Molecular Weight:
444.97
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 876
traceable to Ph. Eur. Y0000650
traceable to USP 1643260

API family

tamsulosin

CofA

current certificate can be downloaded

packaging

ampule of 1 × 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

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1 of 4

This Item
T1330PHR1335PHR1164
format

neat

format

-

format

neat

format

neat

Quality Level

300

Quality Level

100

Quality Level

300

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

storage temp.

-10 to -25°C

storage temp.

room temp

storage temp.

2-30°C

storage temp.

2-8°C

packaging

ampule of 1 × 200 mg

packaging

-

packaging

-

packaging

-

General description

Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist,[1] which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component.[2] It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.[3]

Application

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[1][3][2] using various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Tamsulosin is a α1A/1D-adrenoceptor antagonist; Used as a treatment of BPH (benign prostatic hypertrophy).
Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Development and validation of stability-indicating HPTLC determination of tamsulosin in bulk and pharmaceutical dosage form
    Bari.BS, et al.
    Chromatography Research International, 2011(2), 197-205 (2011)
    Validated RP-HPLC and TLC methods for simultaneous estimation of tamsulosin hydrochloride and finasteride in combined dosage forms
    Patel B.D and Patel J.N
    Acta pharmaceutica, 60(2), 197-205 (2010)
    Validated stability indicating HPTLC method for the determination of Tamsulosin hydrochloride in pharmaceutical dosage forms
    Choudhari.PV and Nikalje GPA
    International Journal of ChemTech Research, 2(1), 646-652 (2010)

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