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PHR1504

Liothyronine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

3,3′,5-Triiodo-L-thyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3

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About This Item

Empirical Formula (Hill Notation):
C15H12I3NO4
CAS Number:
6893-02-3
Molecular Weight:
650.97
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823425
EC Number:
229-999-3
Beilstein/REAXYS Number:
2710227
MDL number:
MFCD00002593

Key Documents

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Product Name

Liothyronine, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

AUYYCJSJGJYCDS-LBPRGKRZSA-N

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

SMILES string

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1368008

API family

liothyronine

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

234-238 °C (lit.)

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... THRA(7067), THRB(7068)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAC2088 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H372

Hazard Classifications

STOT RE 1

target_organs

Thyroid,Cardio-vascular system,Kidney

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Aoife Parsons et al.
Aquatic toxicology (Amsterdam, Netherlands), 209, 99-112 (2019-02-15)
Brominated flame retardants are known to disrupt thyroid hormone (TH) homeostasis in several vertebrate species, but the molecular mechanisms underlying this process and their effects on TH-sensitive tissues during the stages of early development are not well characterised. In this

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