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PHR1498

Supelco

Sulfacetamide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Sulfacetamide, N-(4-Aminobenzenesulfonyl)acetamide, N-(4-Aminophenylsulfonyl)acetamide, N1-Acetylsulfanilamide

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About This Item

Empirical Formula (Hill Notation):
C8H10N2O3S
CAS Number:
144-80-9
Molecular Weight:
214.24
Beilstein:
981718
EC Number:
205-640-6
MDL number:
MFCD00066501
UNSPSC Code:
41116107
PubChem Substance ID:
329823419
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1623808

API family

sulfacetamide

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

InChI key

SKIVFJLNDNKQPD-UHFFFAOYSA-N

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General description

Sulfacetamide is commonly used in ophthalmic preparations, to treat different ocular infections such as cornela ulcers and conjunctivitis. It is generally formulated as a sodium salt and used as 10-30% w/v ophthalmic solution.

Application

Sulfacetamide may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using column chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3046 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H335

Hazard Classifications

Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD3855
LRAC5131
LRAA3046

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Pharmaceutical Chemistry, International Edition (2011)
Pharmacology (2014)
A column chromatographic method for the determination of sulfanilamide in pharmaceutical preparations containing sulfacetamide or its sodium salt
Wojtowicz J.E
Journal of Pharmaceutical Sciences, 59(2), 240-241 (1970)
Piotr Cysewski et al.
International journal of pharmaceutics, 570, 118682-118682 (2019-09-11)
The limited water solubility of sulfonamides provokes a search for new solvents offering not only increased solubility but also environmental and health safety. Therefore, six sulfonamides were studied in a series of natural deep eutectic solvents (NADES) comprising choline chloride

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