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PHR1459

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Chlorhexidine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Chlorhexidine dihydrochloride, 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide), Lisium
Empirical Formula (Hill Notation):
C22H30Cl2N10 · 2HCl
CAS Number:
3697-42-5
Molecular Weight:
578.37
EC Number:
223-026-6
MDL number:
MFCD00068998
UNSPSC Code:
41116107
PubChem Substance ID:
329823393
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. C1540000
traceable to USP 1111103

API family

chlorhexidine

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10.2ClH/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H

InChI key

WJLVQTJZDCGNJN-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlorhexidine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in ointment and pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3007 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Pricing

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Chlorhexidine dihydrochloride, European Pharmacopoeia (EP) Reference Standard

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Chlorhexidine, United States Pharmacopeia (USP) Reference Standard

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Chlorhexidine System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous determination of ingredients in an ointment by hydrophobic interaction electrokinetic chromatography.
Okamoto H, et al.
Journal of Chromatography A, 929(1-2), 133-141 (2001)
Chromatography of crotamiton and its application to the determination of active ingredients in ointments.
Izumoto SI, et al.
Journal of Pharmaceutical and Biomedical Analysis, 15(9-10), 1457-1466 (1997)
Quality Standard research of content determination in Compound Chlorhexidine and Dexamethasone Pellicles [J].
ZHANG B, et al.
Northwest Medicine, 6(9-10), 1457-1466 (2011)

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