PHR1434
Sodium Metabisulfite
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Sodium metabisulfite, Sodium disulfite, Sodium pyrosulfite
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About This Item
Linear Formula:
Na2S2O5
CAS Number:
Molecular Weight:
190.11
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to USP 1614396
API family
sodium metabisulfite
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
>300 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
[Na+].[Na+].[O-]S(=O)S([O-])(=O)=O
InChI
1S/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2
InChI key
HRZFUMHJMZEROT-UHFFFAOYSA-L
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General description
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Sodium Metabisulfite is a sulfiting agent, widely employed as antioxidants, preservatives and browning inhibitors in pharmaceutical formulations and a variety of food and beverages.
Application
Sodium Metabisulfite may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using amperometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAC2953 in the slot below. This is an example certificate only and may not be the lot that you receive.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
Supplementary Hazards
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Amperometric quantification of sodium metabisulfite in pharmaceutical formulations utilizing tetraruthenated porphyrin film modified electrodes and batch injection analysis.
Quintino MSM, et al.
Talanta, 68(4), 1281-1286 (2006)
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Sulfites, preservatives and antioxidants used in the cosmetic, pharmaceutical and food industry are contact allergens whose relevance seems to be difficult to establish. To perform a retrospective study on patients patch tested with a sulfite. Materials and methods. Between 1990
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