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PHR1427

Glycolic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Glycolic acid, Hydroxyacetic acid

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About This Item

Linear Formula:
HOCH2COOH
CAS Number:
79-14-1
Molecular Weight:
76.05
Beilstein:
1209322
EC Number:
201-180-5
MDL number:
MFCD00004312
UNSPSC Code:
41116107
PubChem Substance ID:
329822593
NACRES:
NA.24

Key Documents

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

API family

glycolic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

75-80 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OCC(O)=O

InChI

1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)

InChI key

AEMRFAOFKBGASW-UHFFFAOYSA-N

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General description

Glycolic acid is an α-hydroxy acid with exfoliating and anti-ageing properties. It is useful in dermatology, medical, cosmetics, and pharmaceutical applications.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Glycolic Acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by gas chromatography (GC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3641 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H332

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

>572.0 °F - (decomposition)

Flash Point(C)

> 300 °C - (decomposition)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Glycolic Acid
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 35(6), 6168-6168 (2013)
Applications of hydroxy acids: classification, mechanisms, and photoactivity
Kornhauser A, et al.
Clinical, cosmetic and investigational dermatology, 3, 135?142-135?142 (2010)
Albert D Fraser
Therapeutic drug monitoring, 24(2), 232-238 (2002-03-19)
Metabolic pathways have been elucidated for various chemical and solvent exposures in humans. Clinical laboratory analyses in most chemical and solvent exposures are directed toward identification and quantitation of unchanged substance in serum or whole blood. For example, most laboratories
H Murad et al.
Dermatologic clinics, 13(2), 285-307 (1995-04-01)
Glycolic acid is a member of the AHA family, which occurs naturally in foods and has been used for centuries as a cutaneous rejuvenation treatment. Recently it has proved to be a versatile peeling agent and it is now widely
Rongcai Liang et al.
Pharmaceutical research, 31(8), 1958-1966 (2014-02-20)
To prepare acylated exenatide analogues and investigate their biological properties for guiding the development of PLGA formulations of exenatide. The acylated exenatide analogues were prepared by reaction with glycolic acid (GA), one constitutional unit of PLGA, and characterized by HPLC-MS/MS
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