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PHR1418

Supelco

Succinic Acid

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Succinic acid, Butanedioic acid
Linear Formula:
HOOCCH2CH2COOH
CAS Number:
110-15-6
Molecular Weight:
118.09
Beilstein:
1754069
EC Number:
203-740-4
MDL number:
MFCD00002789
UNSPSC Code:
41116107
PubChem Substance ID:
329823388
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1623411

API family

succinic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

235 °C (lit.)

mp

184-186 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC(=O)CCC(O)=O

InChI

1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

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General description

Succinic acid is a dicarboxylic acid, which is used primarily as an acidity regulator in the food and beverage industry. Pharmaceutically, it is usually used as a conjugate feeder acid to form succinate salt and as an excipient.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Succinic acid may be used as a pharmaceutical reference standard for the determination of the analyte in raw material, food and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2952 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous HPLC determination of organic acids, sugars and alcohols
Doyon G
Can. Inst. Food Sci Technol. J., 24(1-2), 87-94 (1991)
A new HPLC method for simultaneously measuring chloride, sugars, organic acids and alcohols in food samples
Zaky AS
J. Food Compos. Anal., 56(1-2), 25-33 (2017)
Optimization and validation of an HPLC-photodiode array detector method for determination of organic acids in vinegar
Zong Y, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 98(2), 422-430 (2015)
Improving pharmacy students' understanding and long-term retention of acid-base chemistry
Roche VF
American journal of pharmaceutical education, 71(6), 122-122 (2007)
Succinic acid
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 39(2), 6012-6012 (2018)
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