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Lansoprazole

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Lansoprazole, 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl] methyl] sulfinyl]-1H-benzimidazole, LAN
Empirical Formula (Hill Notation):
C16H14F3N3O2S
CAS Number:
103577-45-3
Molecular Weight:
369.36
MDL number:
MFCD00866873
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 872
traceable to Ph. Eur. Y0000773
traceable to USP 1356916

API family

lansoprazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F

InChI

1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)

InChI key

MJIHNNLFOKEZEW-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

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General description

Lansoprazole is an important proton pump inhibitor and a substituted benzimidazole with antisecretory and antiulcer activities. Its mode of action involves the suppression of gastric acid secretion by specific inhibition of the gastric H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Lansoprazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique, kinetic spectrophotometric technique and capillary electrophoresis.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3483 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

Y0000773

Lansoprazole, European Pharmacopoeia (EP) Reference Standard

Y0000774

Lansoprazole for peak identification, European Pharmacopoeia (EP) Reference Standard

1356916

Lansoprazole, United States Pharmacopeia (USP) Reference Standard

1356927

Lansoprazole Related Compound A, United States Pharmacopeia (USP) Reference Standard

1356931

Lansoprazole Related Compound B, United States Pharmacopeia (USP) Reference Standard

BP872

Lansoprazole, British Pharmacopoeia (BP) Reference Standard

BP873

Lansoprazole impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR3019

Lansoprazole Related Compound A, pharmaceutical secondary standard, certified reference material

PHR2956

Lansoprazole Related Compound B, certified reference material, pharmaceutical secondary standard

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The determination of lansoprazole in pharmaceutical preparation by capillary electrophoresis
Dongrukol-Ak D, et al.
Chromatographia, 54(7-8), 527-530 (2001)
A kinetic spectrophotometric method for the determination of lansoprazole in pharmaceutical formulations
Rahman N, et al.
J. Serb. Chem. Soc., 71(10) (2006)
Simultaneous spectrophotometric determination of lansoprazole and domperidone in capsule dosage form
Sherje PA, et al.
Indian Journal of Pharmaceutical Sciences, 70(1), 102-102 (2008)

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