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PHR1376

Loratadine

Name: Loratadine
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Loratadine, 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₃N₂O₂Cl

CAS Number:

79794-75-5

Molecular Weight:

382.88

MDL number:

MFCD00672869

UNSPSC Code:

41116107

PubChem Substance ID:

329823353

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 874
traceable to Ph. Eur. Y0000688
traceable to USP 1370270

API family

loratadine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Loratadine belongs to the class of H1-antihistamine drugs, with non-sedating properties, and is widely used in the treatment of allergies.

Application

Loratadine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Non-sedating histamine H₁-receptor antagonist.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3785 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.

Description

Pricing

1370280

1370270

Loratadine, United States Pharmacopeia (USP) Reference Standard

1370291

1370269

BP874

Loratadine, British Pharmacopoeia (BP) Reference Standard

BP875

Loratadine impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR2308

Loratadine Related Compound B

PHR2309

PHR2313

Loratadine Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2310

Loratadine Impurity A, certified reference material, pharmaceutical secondary standard

PHR2311

Loratadine Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Determination of loratadine in pharmaceuticals by a spectrophotometric method

Pavalanche G, et al.

Ovidius University Annals of Chemistry, 26(1), 27-31 (2015)

Cetirizine and loratadine: minimal risk of QT prolongation.

Prescrire international, 19(105), 26-28 (2010-05-12)

Some antihistamines, such as mizolastine and ebastine, can prolong the QT interval and provoke severe cardiac arrhythmias. This review examines the effects of two widely used antihistamines, cetirizine and loratadine, on the QT interval. As of mid 2009 very few

A review of loratadine in the treatment of patients with allergic bronchial asthma.

J L Menardo et al.

Clinical therapeutics, 19(6), 1278-1293 (1998-01-28)

Patients with seasonal or allergic bronchial asthma experience an immediate allergic response caused by allergen-specific immunoglobulin E-mediated histamine release. The release of histamine and other chemical mediators may trigger airway hyperresponsiveness and exaggerated bronchoconstriction, characteristic features of allergic bronchial asthma.

Risk of hypospadias in offspring of women using loratadine during pregnancy: a systematic review and meta-analysis.

Eleanor B Schwarz et al.

Drug safety, 31(9), 775-788 (2008-08-19)

Loratadine, a second-generation antihistamine, is commonly used to treat seasonal allergies. Some studies have suggested that use of loratadine by pregnant women increases the risk of hypospadias in male offspring. This meta-analysis was designed to assess the strength of the

Loratadine: a nonsedating antihistamine with once-daily dosing.

H A Barenholtz et al.

DICP : the annals of pharmacotherapy, 23(6), 445-450 (1989-06-01)

Loratadine is an addition to the class of nonsedating antihistamines which includes terfenadine, astemizole, and acrivastine. Loratadine is chemically related to the tricyclic antidepressants. Animal data have shown that insignificant amounts of loratadine enter the brain, and it has a

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