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PHR1376

Supelco

Loratadine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Loratadine, 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine

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About This Item

Empirical Formula (Hill Notation):
C22H23N2O2Cl
CAS Number:
79794-75-5
Molecular Weight:
382.88
MDL number:
MFCD00672869
UNSPSC Code:
41116107
PubChem Substance ID:
329823353
NACRES:
NA.24

CN¥2,030.19

Estimated to ship onMay 13, 2025Details

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 874
traceable to Ph. Eur. Y0000688
traceable to USP 1370270

API family

loratadine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

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人纤维连接蛋白 recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

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SRP3186

玻连蛋白 人

Millicoat® Human Collagen Type I Coated Strips (96-Wells) 96-well plate coated with human Collagen Type I used for cell adhesion studies.

ECM104

Millicoat® Human Collagen Type I Coated Strips (96-Wells)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

shipped in

wet ice

shipped in

ambient

shipped in

wet ice

shipped in

wet ice

NCBI accession no.

NM_002026.2, NM_212474.1, NM_212476.1, NM_212482.1, NM_054034.2, NM_212478.1, NM_212475.1

NCBI accession no.

NM_212482.4

NCBI accession no.

NM_000638.4

NCBI accession no.

NM_000088.3

UniProt accession no.

P02751

UniProt accession no.

P02751

UniProt accession no.

P04004

UniProt accession no.

P02452

species reactivity

human

species reactivity

-

species reactivity

-

species reactivity

human

General description

Loratadine belongs to the class of H1-antihistamine drugs, with non-sedating properties, and is widely used in the treatment of allergies.[1]

Application

Loratadine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.[1]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Non-sedating histamine H1-receptor antagonist.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3785 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1370280

Loratadine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1370270

Loratadine, United States Pharmacopeia (USP) Reference Standard

1370291

Loratadine Related Compound B, United States Pharmacopeia (USP) Reference Standard

Y0000603

Loratadine for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0000688

Loratadine, European Pharmacopoeia (EP) Reference Standard

Y0000604

Loratadine impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000605

Loratadine impurity H, European Pharmacopoeia (EP) Reference Standard

1370269

Loratadine Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP874

Loratadine, British Pharmacopoeia (BP) Reference Standard

BP875

Loratadine impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR2308

Loratadine Related Compound B

PHR2309

Loratadine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Standard

PHR2313

Loratadine Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2310

Loratadine Impurity A, certified reference material, pharmaceutical secondary standard

PHR2311

Loratadine Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Determination of loratadine in pharmaceuticals by a spectrophotometric method
    Pavalanche G, et al.
    Ovidius University Annals of Chemistry, 26(1), 27-31 (2015)
    M R Namazi
    Journal of the European Academy of Dermatology and Venereology : JEADV, 19(3), 319-322 (2005-04-29)
    As the current antipsoriatic medications are commonly associated with deleterious side-effects, a determined search for safer agents, which could be used alone or in combination with current antipsoriatic drugs, would be very imperative. Psoriasis is believed to be characterized by
    M Haria et al.
    Drugs, 48(4), 617-637 (1994-10-01)
    Loratadine is a long-acting antihistamine agent, exhibiting partial selectivity for peripheral histamine H1-receptors. To date, loratadine has been evaluated in allergic rhinitis, urticaria and, to a limited extent, in asthma. In several large controlled comparative clinical studies, loratadine was superior
    I J Roman et al.
    Clinical reviews in allergy, 11(1), 89-110 (1993-01-01)
    Antihistamines are considered first-line therapy for the relief of symptoms from allergic rhinitis and chronic urticaria. The newer, second-generation, nonsedating antihistamines reduce the central nervous system and anticholinergic side effects commonly found with previous drugs. The availability of H1-receptor antagonists
    Eleanor B Schwarz et al.
    Drug safety, 31(9), 775-788 (2008-08-19)
    Loratadine, a second-generation antihistamine, is commonly used to treat seasonal allergies. Some studies have suggested that use of loratadine by pregnant women increases the risk of hypospadias in male offspring. This meta-analysis was designed to assess the strength of the
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