Skip to Content

尊敬的客户：

目前国际形势复杂多变，关税政策尚不明朗，这可能对我们的产品价格产生一定影响。在此情况下，我们希望就订单事宜与您进行友好沟通。

基于当前的不确定性，如果您选择在此期间下单，我们将保留根据实际情况调整价格的权利。同时，我们也理解市场变化可能给您带来的困扰，因此如果在订单实际发货前因关税政策变动导致价格出现较大波动，默克将与您进行协商讨论并视情况对订单进行调整或取消。

关于应对近期政策变化的重要更新，请点击此处查看详情。

Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

PHR1353

Supelco

Estradiol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

Sign Into View Organizational & Contract Pricing

Select a Size

5 G
CN¥419.64
10 G
CN¥656.72
50 G
CN¥1,803.15

CN¥419.64

Estimated to ship onMay 23, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 G
CN¥419.64
10 G
CN¥656.72
50 G
CN¥1,803.15

About This Item

Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
50-28-2
Molecular Weight:
272.38
Beilstein:
1914275
EC Number:
200-023-8
MDL number:
MFCD00003693
UNSPSC Code:
41116107
PubChem Substance ID:
329823337
NACRES:
NA.24

CN¥419.64

Estimated to ship onMay 23, 2025Details

Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 729
traceable to Ph. Eur. E1620000
traceable to USP 1250008

API family

estradiol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

176-180 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
D163708274992N9125
N-甲基羟胺 盐酸盐 98%

M50400

N-甲基羟胺 盐酸盐

N,O-二甲基羟胺 盐酸盐 98%

D163708

N,O-二甲基羟胺 盐酸盐

O-乙基羟胺 盐酸盐 97%

274992

O-乙基羟胺 盐酸盐

N-(1-萘基)乙二胺 二盐酸盐 ≥98%

N9125

N-(1-萘基)乙二胺 二盐酸盐

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mp

86-88 °C (lit.)

mp

112-115 °C

mp

130-133 °C (lit.)

mp

194-198 °C (dec.) (lit.)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Estradiol is a steroid hormone present naturally in the human body. The availability of this hormone is quintessential in older women as it is a determinant of menopausal syndromes. It is utilized for the prevention of cardiovascular diseases.[1]

Application

Estradiol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.[2][1][3][4]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary.
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3704 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

1250008

Estradiol, United States Pharmacopeia (USP) Reference Standard

Y0000314

Estradiol for peak identification, European Pharmacopoeia (EP) Reference Standard

E1620000

Estradiol hemihydrate, European Pharmacopoeia (EP) Reference Standard

E1600000

Estradiol benzoate, European Pharmacopoeia (EP) Reference Standard

Y0000046

Estradiol valerate, European Pharmacopoeia (EP) Reference Standard

Y0000852

Estradiol benzoate for system suitability, European Pharmacopoeia (EP) Reference Standard

1252003

Estradiol cypionate, United States Pharmacopeia (USP) Reference Standard

1251000

Estradiol benzoate, United States Pharmacopeia (USP) Reference Standard

BP729

Estradiol hemihydrate, British Pharmacopoeia (BP) Assay Standard

1254009

Estradiol valerate, United States Pharmacopeia (USP) Reference Standard

1250041

Estradiol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1250020

Estradiol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1252193

Estradiol cypionate System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

Y0001823

Estradiol valerate for system suitability, European Pharmacopoeia (EP) Reference Standard

BP396

Estradiol benzoate, British Pharmacopoeia (BP) Reference Standard

1254031

Estradiol Valerate Identification Mixture, United States Pharmacopeia (USP) Reference Standard

PHR2228

Estradiol 3-Methyl Ether, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2227

Estradiol Impurity L, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2839

Estradiol Cypionate, certified reference material, pharmaceutical secondary standard

PHR2857

Estradiol Valerate, certified reference material, pharmaceutical secondary standard

PHR2858

Estradiol Benzoate, certified reference material, pharmaceutical secondary standard

PHR2859

Estradiol Related Compound C, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Danger

Hazard Statements

H351,H360FD,H362,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

    If you need assistance, please contact Customer Support.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    High-efficiency liquid chromatography in pharmaceutical analysis
    Bailey F. and Brittain PN
    Journal of Chromatography A, 83(3), 431-437 (1973)
    Prediction of internal standards in reversed-phase liquid chromatography: II. Selectivity optimization and internal standard prediction for the quantitation of estradiol and levonorgestrel in a transdermal drug delivery formulation based on the linear solvation energy relationships
    Li, J and Shah DS
    Journal of Chromatography A, 954(1), 159-171 (2002)
    HPLC determination of estradiol, its degradation product, and preservatives in new topical formulation Estrogel HBF.
    Novakova L, et al.
    Analytical and Bioanalytical Chemistry, 379(5-6), 781-787 (2004)
    Advantages of application of UPLC in pharmaceutical analysis.
    Novakova L, et al.
    Talanta, 68(3), 908-918 (2006)
    Marie Mi Bonde et al.
    Nucleic acids research, 42(20), 12847-12860 (2014-10-30)
    Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity. We calculated the escape rate for the yeast PTC7 intron
    View All Related Papers

    Articles

    Ultrapure Water for LC MS Biomedical Analyses

    This study assesses the suitability of ultrapure water from a Milli-Q® water system for sensitive LC-MS analyses of hormones.

    LC-MS Analysis of Hormones in Tap Water

    Milli-Q® ultrapure water systems deliver water free of organic contaminants , including hormones present in a lab's tap water, making it suitable for the most sensitive LC-MS/MS analyses.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service