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PHR1325

Supelco

Oxytetracycline Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Oxytetracycline hydrochloride, 5-Hydroxytetracycline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H24N2O9 · HCl
CAS Number:
2058-46-0
Molecular Weight:
496.89
Beilstein:
3853107
EC Number:
218-161-2
MDL number:
MFCD00135815
UNSPSC Code:
41116107
PubChem Substance ID:
329823310
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 275
traceable to Ph. Eur. O0500000
traceable to USP 1491015

API family

oxytetracycline

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

Cl.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1

InChI key

UBDNTYUBJLXUNN-IFLJXUKPSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Oxytetracycline is a broad-spectrum antibiotic drug widely employed in veterinary applications, particularly for the management of infections in pig productions. It acts by inhibiting the protein synthesis in gram-positive and gram-negative bacteria.

Application

Oxytetracycline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0828 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1491015

Oxytetracycline hydrochloride, United States Pharmacopeia (USP) Reference Standard

1491004

Oxytetracycline, United States Pharmacopeia (USP) Reference Standard

O0500000

Oxytetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

PHR1537

Oxytetracycline, Pharmaceutical Secondary Standard; Certified Reference Material

BP782

Oxytetracycline, British Pharmacopoeia (BP) Reference Standard

BP275

Oxytetracycline hydrochloride, British Pharmacopoeia (BP) Reference Standard

Y0002136

Oxytetracycline for system suitability A, European Pharmacopoeia (EP) Reference Standard

PHR8912

alpha-Apo-oxytetracycline, certified reference material, pharmaceutical secondary standard

PHR8913

beta-Apo-oxytetracycline, certified reference material, pharmaceutical secondary standard

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD6787
LRAD2280
LRAC3219
LRAA0828
LRAA9119

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Determination of oxytetracycline and its degradation products by high-performance liquid chromatography-tandem mass spectrometry in manure-containing anaerobic test systems
Loke ML, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 783(1), 11-23 (2003)
Determination of oxytetracycline and doxycycline in pharmaceutical compounds, urine and honey by derivative spectrophotometry
Salinas F, et al.
Analyst, 114(9), 1141-1145 (1989)
Simultaneous determination of sulfathiazole and oxytetracycline in honey by derivative spectrophotometry
Salinas F, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 43(3), 244-252 (1991)
C18 columns for the simultaneous determination of oxytetracycline and its related substances by reversed-phase high performance liquid chromatography and UV detection.
Smyrniotakis CG and Archontaki HA
Journal of Pharmaceutical and Biomedical Analysis, 43(2), 506-514 (2007)
Zhenxing Chi et al.
PloS one, 9(7), e102334-e102334 (2014-07-16)
The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs.
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