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PHR1307

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Captopril

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
Empirical Formula (Hill Notation):
C9H15NO3S
CAS Number:
62571-86-2
Molecular Weight:
217.29
Beilstein:
477887
EC Number:
263-607-1
MDL number:
MFCD00168073
UNSPSC Code:
41116107
PubChem Substance ID:
329823294
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 538
traceable to Ph. Eur. C0430000
traceable to USP 1091200

API family

captopril

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

104-108 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

Gene Information

human ... ACE(1636)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Captopril acts by inhibiting the angiotensin-converting enzyme and is known as an antihypertensive agent. It finds wide use in the treatment of congestive heart failure.

Application

Captopril may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0067 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1091200

Captopril, United States Pharmacopeia (USP) Reference Standard

1091221

Captopril disulfide, United States Pharmacopeia (USP) Reference Standard

C0430000

Captopril, European Pharmacopoeia (EP) Reference Standard

Y0000435

Captopril impurity E, European Pharmacopoeia (EP) Reference Standard

Y0001182

Captopril for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001221

Captopril impurity D, European Pharmacopoeia (EP) Reference Standard

Y0001219

Captopril impurity B, European Pharmacopoeia (EP) Reference Standard

Y0001220

Captopril impurity C, European Pharmacopoeia (EP) Reference Standard

Y0001450

Captopril impurity J, European Pharmacopoeia (EP) Reference Standard

BP538

Captopril, British Pharmacopoeia (BP) Reference Standard

BP500

Captopril disulfide, British Pharmacopoeia (BP) Reference Standard

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H341,H360F

Hazard Classifications

Muta. 2 - Repr. 1B

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of captopril and its degradation products by capillary electrophoresis
Hillaert S and Van den Bossche W
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 65-73 (1999)
Validation of simultaneous volumetric and spectrophotometric methods for the determination of captopril in pharmaceutical formulations
Rahman N, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(6-7), 569-574 (2005)
Square-wave voltammetric (SWV) determination of Captopril in reconstituted serum and pharmaceutical formulations
Parham H and Zargar B
Talanta, 65(3), 776-780 (2005)
Analysis of captopril and hydrochlorothiazide combination tablet formulations by liquid chromatography
Kirschbaum J and Perlman S
Journal of Pharmaceutical Sciences, 73(5), 686-687 (1984)
Potentiometric determination of captopril in pharmaceutical formulations
Ribeiro PRDS, et al.
Ecletica Quimica , 28(1), 39-44 (2003)
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