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PHR1285

Supelco

Lovastatin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Lovastatin, Mevinolin

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100 TESTS
CN¥13,220.39

CN¥13,220.39

Estimated to ship onAugust 05, 2025Details

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100 TESTS
CN¥13,220.39

About This Item

Empirical Formula (Hill Notation):
C24H36O5
CAS Number:
75330-75-5
Molecular Weight:
404.54
UNSPSC Code:
41116107
NACRES:
NA.24

CN¥13,220.39

Estimated to ship onAugust 05, 2025Details

Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. L0790000
traceable to USP 1370600

API family

lovastatin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

O1[C@@H](C[C@H](CC1=O)O)CC[C@@H]2[C@H]3[C@H](C[C@H](C=C3C=C[C@@H]2C)C)OC(=O)[C@H](CC)C

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71005BC

GDS Shiga Toxin Genes (O157) Tq

GDS MPX Top 7 STEC BioControl, Molecular based PCR test for the detection of E. coli O157:H7 and the "Top Six" non-O157 Shiga Toxigenic E. coli (STEC) in food

71015BC

GDS MPX Top 7 STEC

manufacturer/tradename

Assurance GDS®, BioControl Systems 71018-100

manufacturer/tradename

Assurance GDS®, BioControl Systems 71017-100

manufacturer/tradename

Assurance GDS®, BioControl Systems 71005-100

manufacturer/tradename

Assurance GDS®, BioControl Systems 71015-100, BioControl Systems 71015-576

suitability

enterovirulent E. coli (EEC) (shiga toxigenic)

suitability

enterovirulent E. coli (EEC) (shiga toxigenic)

suitability

Escherichia coli (O157:H7)

suitability

enterovirulent E. coli (EEC) (shiga toxigenic)

compatibility

for use with GDS Rotor-Gene

compatibility

for use with GDS Rotor-Gene

compatibility

for use with GDS Rotor-Gene

compatibility

for use with GDS Rotor-Gene

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

General description

Lovastatin, an orally administered drug, is a lactone metabolite used for the treatment of hypercholesterolemia and coronary heart diseases. It is a hexahydronaphtalene drug, belonging to the class of HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase inhibitors.[1][2][3][4][5][6]
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Lovastatin may find its use as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric[7][4][8][9][10], thermal characterization,[7][8] and chromatographic techniques.[4][5][8]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3329 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351,H361f

Hazard Classifications

Carc. 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Lovastatin decreases coenzyme Q levels in humans.
    Folkers K, et al.
    Proceedings of the National Academy of Sciences of the USA, 87(22), 8931-8934 (1990)
    Development and validation of a simple and fast HPLC method for determination of lovastatin, pravastatin and simvastatin
    Silva TD, et al.
    Journal of Chromatographic Science, 50(9), 831-838 (2012)
    Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS
    Downs JR, et al.
    JAMA : The Journal of the American Medical Association, 279(20), 1615-1622 (1998)
    Colorimetric determination of simvastatin and lovastatin in pure form and in pharmaceutical formulations
    El-Din Mohie MKS, et al.
    Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 76(3-4), 423-428 (2010)
    Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins
    Novakova L, et al.
    Talanta, 78(3), 834-839 (2009)
    View All Related Papers

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