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Merck
CN

PHR1274

Melamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2,4,6-Triamino-1,3,5-triazine, sym-Triaminotriazine

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About This Item

Empirical Formula (Hill Notation):
C3H6N6
CAS Number:
108-78-1
Molecular Weight:
126.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823270
EC Number:
203-615-4
Beilstein/REAXYS Number:
124341
MDL number:
MFCD00006055

Key Documents

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Product Name

Melamine, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

JDSHMPZPIAZGSV-UHFFFAOYSA-N

InChI

1S/C3H6N6/c4-1-7-2(5)9-3(6)8-1/h(H6,4,5,6,7,8,9)

SMILES string

Nc1nc(N)nc(N)n1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1379183

API family

melamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Melamine is a nitrogen-rich chemical employed in the production of plastics, resins, laminates, adhesives as well as flame retardants. It may also be utilized as a fertilizer. It is one of the metabolites of cyromazine, which is approved for use as an insecticide on a wide range of vegetable crops.
This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3464 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Carc. 2 - Repr. 2 - STOT RE 2

target_organs

Urinary tract

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

572.0 °F - closed cup

flash_point_c

300 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Method development and validation for melamine and its derivatives in rice concentrates by liquid chromatography. Application to animal feed samples
Mu?iz-Valencia R, et al.
Analytical and Bioanalytical Chemistry, 392(3), 523-531 (2008)
Sana Jawaid et al.
Food chemistry, 141(3), 3066-3071 (2013-07-23)
Melamine is a nitrogenous chemical substance used principally as a starting material for the manufacture of synthetic resins. Due to its very high proportion of nitrogen melamine has been added illegitimately to foods and feeds to increase the measured protein
Yu-Chang Tyan et al.
Analytical and bioanalytical chemistry, 395(3), 729-735 (2009-08-12)
In the summer of 2008, serious illnesses and deaths of babies in China were linked to melamine-tainted powdered infant formula. Melamine contains several metabolites, such as ammeline, ammelide, and cyanuric acid, and has been used for the adulteration of foods
Lingjie Kong et al.
Optics letters, 38(2), 145-147 (2013-03-05)
Stimulated Raman scattering (SRS) microscopy allows label-free chemical imaging based on vibrational spectroscopy. Narrowband excitation with picosecond lasers creates the highest signal levels and enables imaging speeds up to video-rate, but it sacrifices chemical specificity in samples with overlapping bands
Yanhua Zhao et al.
Talanta, 113, 7-13 (2013-05-28)
Silver nanoparticles coated amino modified polystyrene microspheres (PS-NH2/Ag NPs) with extremely high surface enhanced Raman scattering (SERS) activity and uniform surface morphology were created by precise controlling of deposition time. Nanojets that were formed underneath the individual microspheres could be
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