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PHR1270

Fumaric Acid

Name: Fumaric Acid
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Fumaric acid

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About This Item

Linear Formula:

HOOCCH=CHCOOH

CAS Number:

110-17-8

Molecular Weight:

116.07

Beilstein:

605763

EC Number:

203-743-0

MDL number:

MFCD00002700

UNSPSC Code:

41116107

PubChem Substance ID:

329823266

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. F0600000
traceable to USP 1286708

vapor pressure

1.7 mmHg ( 165 °C)

API family

fumaric acid

CofA

current certificate can be downloaded

autoignition temp.

1364 °F

expl. lim.

40 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

298-300 °C (subl.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)\C=C\C(O)=O

InChI

1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+

InChI key

VZCYOOQTPOCHFL-OWOJBTEDSA-N

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Fumaric Acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC1693 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2

WGK

WGK 1

Flash Point(F)

open cup

Flash Point(C)

open cup

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Spectrophotometric estimation of ketotifen fumarate in pharmaceutical formulations

Sastry CSP and Naidu PY

Microchimica Acta, 127(3-4), 219-223 (1997)

Spectrophotometric determination of ascorbic acid in pharmaceuticals by background correction and flow injection

Verma KK, et al.

Analyst, 116(6), 641-645 (1991)

Fumaric acid and its esters: an emerging treatment for multiple sclerosis with antioxidative mechanism of action.

R Gold et al.

Clinical immunology (Orlando, Fla.), 142(1), 44-48 (2011-03-19)

Fumaric acid was originally therapeutically used in psoriasis. Several lines of evidence have demonstrated immunomodulatory but also neuroprotective effects for FAE. Clinical studies in psoriasis showed a reduction of peripheral CD4+ and CD8+ T-lymphocytes due to the ability of FAE

Management of psoriasis vulgaris and multiple sclerosis with fumaric acid.

Spyridon Gkalpakiotis et al.

Journal of the American Academy of Dermatology, 70(3), e60-e61 (2014-02-18)

[Immunomodulation with fumaric acid. Systemic therapy in psoriasis].

B Sebók et al.

Orvosi hetilap, 141(3), 129-132 (2000-02-29)

The treatment of psoriasis vulgaris with fumaric acid esters has been controversial for more than 30 years. Recently the fumaric acid derivatives are marketed antipsoriatics in many European countries. In this paper the clinical efficacy, the side effects as well

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