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PHR1237

Supelco

Cholecalciferol (Vitamin D3)

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Cholecalciferol, (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol

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500 MG
¥1,756.25

¥1,756.25

Available to ship on2025年4月23日Details

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500 MG
¥1,756.25

About This Item

Empirical Formula (Hill Notation):
C27H44O
CAS Number:
67-97-0
Molecular Weight:
384.64
Beilstein:
2339331
EC Number:
200-673-2
MDL number:
MFCD00078131
UNSPSC Code:
41116107
PubChem Substance ID:
329823242
NACRES:
NA.24

¥1,756.25

Available to ship on2025年4月23日Details

Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 787
traceable to Ph. Eur. C2100000
traceable to USP 1131009

API family

cholecalciferol

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

83-86 °C (lit.)

application(s)

food and beverages

format

neat

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This Item
47763C2100000C2150000
胆钙化醇 Pharmaceutical Secondary Standard; Certified Reference Material

PHR1237

胆钙化醇

胆钙化固醇（维生素 D3） analytical standard

47763

胆钙化固醇（维生素 D3）

胆钙化醇 European Pharmacopoeia (EP) Reference Standard

C2100000

胆钙化醇

胆钙化醇 European Pharmacopoeia (EP) Reference Standard

C2150000

胆钙化醇

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

form

solid

form

solid

form

solid

form

solid

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

100

Quality Level

-

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

analytical standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cholecalciferol (vitamin D3) is a fat-soluble vitamin that manifests skeletal and extra-skeletal effects. The skeletal effects augment the bone health whereas the extra-skeletal effects concern the immune system, the cognition, the cardiovascular system, etc.[1]

Application

Cholecalciferol (Vitamin D3) may be used as a pharmaceutical reference standard for the determination of the analyte in food, feeds,[2] serum samples[3] and pharmaceutical formulations[4][2][3] by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
Vitamin D acts through a receptor that modulates the proliferation and differentiation of both normal and cancer cells.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0270 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300 + H310 + H330,H372

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    High-performance liquid chromatographic determination of vitamin D in foods, feeds and pharmaceuticals by successive use of reversed-phase and straight-phase columns
    TAKEUCHI A, et al.
    Journal of nutritional science and vitaminology, 30(1), 11-25 (1984)
    Simultaneous microemulsion liquid chromatographic analysis of fat-soluble vitamins in pharmaceutical formulations: optimization using genetic algorithm
    Momenbeik F, et al.
    Journal of Chromatography A, 1217(24), 3770-3773 (2010)
    Is supercritical fluid chromatography hyphenated to mass spectrometry suitable for the quality control of vitamin D3 oily formulations?
    Andri B, et al.
    Journal of Chromatography A, 1515(5-6), 209-217 (2017)
    Determination of vitamins A, D, E, and K in human and bovine serum, and ?-carotene and vitamin A palmitate in cosmetic and pharmaceutical products, by isocratic HPLC
    Wang LH and Huang SH
    Chromatographia, 55(5-6), 289-296 (2002)
    Hongliu Ding et al.
    Neurology, 81(17), 1531-1537 (2013-09-27)
    To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD). We used liquid chromatography/tandem mass spectrometry to establish
    View All Related Papers

    Protocols

    AOAC Method 2011.11: UHPLC/MS/MS Analysis of Vitamin D2 and Vitamin D3 on Titan™ C18

    Separation of Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard

    HPLC Analysis of Vitamin D2 and D3

    Ascentis Express C18 is suitable for routine analysis of fat-soluble vitamins D2 and D3, providing optimized chromatograms.

    HPLC Analysis of Fat Soluble Vitamins by Normal Phase Chromatography on Ascentis® Si

    Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard

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