PHR1227
Fluorouracil
Pharmaceutical Secondary Standard; Certified Reference Material
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to BP 995
traceable to Ph. Eur. F0250000
traceable to USP 12790000
API family
fluorouracil
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
282-286 °C (dec.) (lit.)
application(s)
cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
Gene Information
human ... TYMS(7298)
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General description
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.
Application
Analysis Note
Other Notes
Footnote
Recommended products
related product
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
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The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Why does the 5-Fluorouracil have no effect on my cell line, even at micromolar concentrations that should be more than high enough?
Some cells, and in particular cancer cells, may be resistant to 5-fluorouracil. Please see this paper Huanwen, W., et al., Molecular Cancer, 8, 125 (2009) which addresses this observation, as well as references 16 and 30 in this publication.If the cells are treated with the closely related gemcitabine (Sigma-Aldrich Product G6423), and cell growth is not inhibited by that drug either, you will have shown that the "problem" is with the cell line, and not with the drug(s).
Do you have 5-FU (5-Fluorouracil) for injection? If not, how can I prepare it from the powder?
Sigma-Aldrich lists several fluorouracil products, but we do not offer Fluorouracil for injection. Our 5-Fluorouracil (5-FU) products cannot be given to human patients. (Note that although Product F8423 meets USP testing specifications, it is not a pharmaceutical grade or PharmaGrade product.)Having said that, a solution for injection into research animals could be prepared the same way as the Fluorouracil Injection, USP is. According to the drugs.com, "Fluorouracil Injection, USP, an antineoplastic anti-metabolite, is a colorless to yellow aqueous sterile, nonpyrogenic injectable solution for intravenous administration. Each mL contains: 50 mg fluorouracil; pH is adjusted to 8.6 to 9.4 with sodium hydroxide".
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