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PHR1224

Supelco

Aminocaproic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

6-Aminocaproic acid, ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA

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About This Item

Linear Formula:
H2N(CH2)5CO2H
CAS Number:
60-32-2
Molecular Weight:
131.17
Beilstein:
906872
EC Number:
200-469-3
MDL number:
MFCD00008238
UNSPSC Code:
41116107
PubChem Substance ID:
329823230
NACRES:
NA.24
Pricing and availability is not currently available.

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. A0420000
traceable to USP 1021000

API family

aminocaproic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

207-209 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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This Item
SAB4200714H4149WH0003304M2
Monoclonal Anti-Heat Shock Protein 70 antibody produced in mouse clone BRM-22, ascites fluid

H5147

Monoclonal Anti-Heat Shock Protein 70 antibody produced in mouse

Anti-Heat Shock Protein 70 (HSP70) antibody, Mouse monoclonal clone BRM-22, purified from hybridoma cell culture

SAB4200714

Anti-Heat Shock Protein 70 (HSP70) antibody, Mouse monoclonal

Monoclonal Anti-Heat Shock Protein 60 antibody produced in mouse clone LK1, ascites fluid

H4149

Monoclonal Anti-Heat Shock Protein 60 antibody produced in mouse

Monoclonal Anti-HSPA1B antibody produced in mouse clone 3B7, purified immunoglobulin, buffered aqueous solution

WH0003304M2

Monoclonal Anti-HSPA1B antibody produced in mouse

Gene Information

human ... HSPA1A(3303), HSPA1B(3304)
rat ... Hspa1a(24472), Hspa1b(294254)

Gene Information

human ... HSPA1A(3303)
mouse ... HSPA1A(193740)
rat ... HSPA1A(24472)

Gene Information

human ... HSPD1(3329)
rat ... Hspd1(63868)

Gene Information

human ... HSPA1B(3304)

biological source

mouse

biological source

-

biological source

mouse

biological source

mouse

clone

BRM-22, monoclonal

clone

BRM-22, monoclonal

clone

LK1, monoclonal

clone

3B7, monoclonal

species reactivity

bovine, chicken, guinea pig, plant, Drosophila, rat, human, nematode, rabbit, hamster

species reactivity

plant, bovine, rabbit, chicken, human, fish, insect, monkey, dog, rat, sea urchin, mouse

species reactivity

rat, human, chicken

species reactivity

mouse, human, rat

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

antibody form

purified immunoglobulin

General description

Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia.[1][2]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Aminocaproic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[3] by fluorimetry and in bulk and injectable forms[4] using colorimetric method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9036 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Aminocaproic acid: use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia
Gardner FH and Helmer RE
JAMA : The Journal of the American Medical Association, 243(1), 35-37 (1980)
The absorption, distribution, and excretion of ?-aminocaproic acid following oral or intravenous administration to man
McNicol GP, et al.
The Journal of Laboratory and Clinical Medicine, 59(1), 15-24 (1962)
Fluorimetric determination of aminocaproic acid in pharmaceutical formulations using a sequential injection analysis system
Pinto PCAG, et al.
Talanta, 68(3), 857-862 (2006)
Development of Colorimetric Method for the Analysis of Aminocaproic Acid Using DCQ
Shantier SW, et al.
World Journal of Pharmaceutical Research, 4(4), 234-240 (2015)
P A Stricker et al.
British journal of anaesthesia, 110(5), 788-799 (2013-01-29)
Understanding the clinical pharmacology of the antifibrinolytic epsilon-aminocaproic acid (EACA) is necessary for rational drug administration in children. The aim of this study is to determine the pharmacokinetics (PKs) of EACA in infants aged 6-24 months undergoing craniofacial reconstruction surgery.
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