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PHR1220

Supelco

Diethanolamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2,2′-Iminodiethanol, Bis(2-hydroxyethyl)amine

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About This Item

Linear Formula:
HN(CH2CH2OH)2
CAS Number:
111-42-2
Molecular Weight:
105.14
Beilstein:
605315
EC Number:
203-868-0
MDL number:
MFCD00002843
UNSPSC Code:
41116107
PubChem Substance ID:
329823227
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1192808

vapor density

3.6 (vs air)

vapor pressure

<0.98 atm ( 100 °C)

API family

diethanolamine

CofA

current certificate can be downloaded

autoignition temp.

689 °F

expl. lim.

10.6 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.477 (lit.)

bp

217 °C/150 mmHg (lit.)

mp

28 °C (lit.)

density

1.097 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OCCNCCO

InChI

1S/C4H11NO2/c6-3-1-5-2-4-7/h5-7H,1-4H2

InChI key

ZBCBWPMODOFKDW-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Diethanolamine is commonly used as a chemical intermediate and as a surface-active agent in agricultural products, pharmaceutical formulations and cosmetics.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Ion Mobility: TWCCSN2 value of 119.8 Å2 [M+H]+

The collision cross section (CCS) measurement was provided by Waters Corporation, using the SYNAPT XS mass spectrometer.
For a description and overview of how ion mobility enables the measurement of the CCS of an ion visit ims.waters.com.
Further information on the SYNAPT XS mass spectrometer can be found on the IMS microsite and product webpage.

TWCCS measurements are expected to be within 2% of this reference value.

P/N PHR1220 is part of the Waters Extractables & Leachables UNIFI scientific library which can be downloaded from Waters Marketplace.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3260 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Oral

Target Organs

Kidney,Liver,Blood

WGK

WGK 2

Flash Point(F)

280.4 °F

Flash Point(C)

138 °C

Regulatory Information

危险化学品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC3260
P500220
LRAA9033

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Ecotoxicological evaluation of diethanolamine using a battery of microbiotests
Zurita LJ, et al.
Toxicology in vitro, 19(7), 879-886 (2005)
S H Zeisel et al.
The Biochemical journal, 232(2), 403-408 (1985-12-01)
An understanding of the biosynthesis and metabolism of dimethylamine (DMA) is important because it is a precursor of dimethylnitrosamine (nitroso-DMA). DMA is the major short-chain aliphatic amine in human and rat urine. DMA is formed from trimethylamine (TMA), which, in
Daniel R Fandrick et al.
Organic letters, 11(23), 5458-5461 (2009-11-03)
The utility of propargyl diethanolamine boronates as reagents for the preparation of allenes and homopropargylic alcohols is presented. Protonolysis with TFA and electrophilic substitution with N-halosuccinimides proceeded with inversion to provide the corresponding allene in high yield and regioselectivity. Alternatively
L Jiménez et al.
Bioresource technology, 100(3), 1478-1481 (2008-09-24)
The AOpAZRP bleaching sequence (A is an acid treatment, Op an oxygen and peroxide stage, Z an ozone stage, R a reductive treatment and P a peroxide stage) have been applied to oil palm empty fruit bunches (EFB) soda-anthraquinone and
Bjørn Henrik Hansen et al.
Aquatic toxicology (Amsterdam, Netherlands), 99(2), 212-222 (2010-06-12)
Alkanolamines are surface-active chemicals used in a wide range of industrial, agricultural and pharmaceutical applications and products. Of particular interest is the use of alkanolamines such as diethanolamine (DEA) in the removal of CO(2) from natural gas and for CO(2)
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