PHR1214
Methyl salicylate
Pharmaceutical Secondary Standard; Certified Reference Material
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Synonym(s):
2-Hydroxybenzoic acid methyl ester, Methyl 2-hydroxybenzoate, Oil of wintergreen, Wintergreen oil
Linear Formula:
2-(HO)C6H4CO2CH3
CAS Number:
Molecular Weight:
152.15
Beilstein:
971516
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to USP 1537450
vapor density
5.26 (vs air)
vapor pressure
1 mmHg ( 54 °C)
API family
methyl salicylate
CofA
current certificate can be downloaded
autoignition temp.
847 °F
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.536 (lit.)
bp
222 °C (lit.)
mp
−8-−7 °C (lit.)
density
1.174 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
COC(=O)c1ccccc1O
InChI
1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3
InChI key
OSWPMRLSEDHDFF-UHFFFAOYSA-N
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Methyl salicylate is one of the common ingredients present in topical analgesics and rubifacients. It is prescribed for the management of minor muscle aches and pains.
Methyl salicylate is one of the common ingredients present in topical analgesics and rubifacients. It is prescribed for the management of minor muscle aches and pains.
Application
Methyl salicylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and voltammetry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAC3556 in the slot below. This is an example certificate only and may not be the lot that you receive.
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Sens. 1B
WGK
WGK 2
Flash Point(F)
204.8 °F
Flash Point(C)
96 °C
Certificates of Analysis (COA)
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Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation
Pauwels J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 60(3), 51-58 (2012)
Determination of salicylic acid in pharmaceutical formulations and foods by differential-pulse voltammetry using a glassy carbon electrode
Fung YS and Luk SF
Analyst, 114(8), 943-945 (1989)
Agata Bartyzel et al.
Analytica chimica acta, 707(1-2), 204-209 (2011-10-27)
N,N'-bis-(α-methylsalicylidene)-2,2-dimethyl-1,3-propanediimine (SBTD) modified silica gel was prepared and used as sorbent for solid phase extraction of Cr(III) ions from aqueous solution. This sorbent showed a high sorption affinity for Cr(III) while recovery of Cr(VI) was very low. The analyte ion
J S Valdez et al.
Journal of chromatography. B, Biomedical sciences and applications, 729(1-2), 163-171 (1999-07-20)
Analytical methods using gas chromatography-flame ionization detection (GC-FID) for the quantitation of camphor and menthol and GC-MS for the quantitation of methyl salicylate have been developed for measurement of low concentrations from human plasma. Anethole serves as the internal standard
Youli Yao et al.
The Plant cell, 23(10), 3842-3852 (2011-10-27)
We have previously shown that local exposure of plants to stress results in a systemic increase in genome instability. Here, we show that UV-C-irradiated plants produce a volatile signal that triggers an increase in genome instability in neighboring nonirradiated Arabidopsis
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