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PHR1197

Supelco

Iminostilbene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

5H-Dibenz[b,f]azepine, Carbamazepine Related Compound B, Iminostilbene

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About This Item

Empirical Formula (Hill Notation):
C14H11N
CAS Number:
256-96-2
Molecular Weight:
193.24
Beilstein:
1343358
EC Number:
205-970-0
MDL number:
MFCD00005071
UNSPSC Code:
41116107
PubChem Substance ID:
329823205
NACRES:
NA.24

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1093023

API family

carbamazepine, oxcarbazepine 

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

196-199 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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Hamilton® 注射器，1700 系列 1725N, volume 250 μL, needle size 22s ga (bevel tip), needle L 51 mm (2 in.)

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Hamilton® 注射器，1700 系列 1710N, volume 100 μL, needle size 22s ga (bevel tip), needle L 51 mm (2 in.)

20688

Hamilton® 注射器，1700 系列

Hamilton® 注射器，1700 系列 1701N, volume 10 μL, needle size 26s ga (bevel tip), needle L 51 mm (2 in.)

20972

Hamilton® 注射器，1700 系列

Hamilton® 注射器，1700 系列 1702N, volume 25 μL, needle size 22s ga (bevel tip), needle L 51 mm (2 in.)

20973

Hamilton® 注射器，1700 系列

packaging

pkg of 1 ea

packaging

pkg of 1 ea

packaging

pkg of 1 ea

packaging

pkg of 1 ea

needle size

22s ga (bevel tip)

needle size

22s ga (bevel tip)

needle size

26s ga (bevel tip)

needle size

22s ga (bevel tip)

description

Gastight®

description

Gastight®

description

Gastight®

description

Gastight®

feature

needle type N (cemented)

feature

needle type N (cemented)

feature

needle type N (cemented)

feature

needle type N (cemented)

manufacturer/tradename

Hamilton 81100

manufacturer/tradename

Hamilton 81000

manufacturer/tradename

Hamilton 80000

manufacturer/tradename

Hamilton 80200

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards..

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9013 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Carbamazepine impurity A, European Pharmacopoeia (EP) Reference Standard

C0450000

Carbamazepine, European Pharmacopoeia (EP) Reference Standard

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Carbamazepine Related Compound B, United States Pharmacopeia (USP) Reference Standard

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Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H411

Precautionary Statements

P273

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Koleta Hemine et al.
    Carbohydrate polymers, 250, 116957-116957 (2020-10-15)
    It is widely believed that the hydrophobic effect governs the binding of guest molecules to cyclodextrins (CDs). However, it is also known that high hydrophobicity of guest molecules does not always translate to the formation of stable inclusion complexes with
    S M Furst et al.
    Drug metabolism and disposition: the biological fate of chemicals, 23(5), 590-594 (1995-05-01)
    Carbamazepine therapy is associated with several types of idiosyncratic drug reactions, including hematological disorders. In previous studies, we found that carbamazepine was metabolized by the myeloperoxidase/H2O2 system of activated neutrophils, and covalent binding of the drug to neutrophils was observed.
    Ying Wu et al.
    The Journal of allergy and clinical immunology, 118(1), 233-241 (2006-07-04)
    T-cell-mediated hypersensitivity is a rare but serious manifestation of drug therapy. To explore the mechanisms of drug presentation to T cells and the possibility that generation of metabolite-specific T cells may provoke cross-sensitization between drugs. A lymphocyte transformation test was
    Predrag Lj Dzodić et al.
    Journal of AOAC International, 93(4), 1059-1068 (2010-10-07)
    An accurate and precise RP-HPLC method was developed and validated for the determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in a tablet formulation with fluphenazine as an internal standard. Buffer-methanol (50 + 50, v/v) was used as the
    Olivier Mathieu et al.
    Pharmacological reports : PR, 63(1), 86-94 (2011-03-29)
    Carbamazepine is a widely used anticonvulsive agent. Its metabolic pathway leads not only to the major active metabolite, carbamazepine-10,11-epoxide, but also to minor terminal metabolites such as iminostilbene and acridine. Carbamazepine is usually well-tolerated, but it may lead to rare
    View All Related Papers

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