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PHR1196

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Nitrofurazone

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
5-Nitro-2-furaldehyde semicarbazone, NZ, Nitrofural, 5-Nitro-2-furfural semicarbazone, Furacin, NFZ, Nitrofurazone
Empirical Formula (Hill Notation):
C6H6N4O4
CAS Number:
59-87-0
Molecular Weight:
198.14
Beilstein:
86403
EC Number:
200-443-1
MDL number:
MFCD00003225
UNSPSC Code:
41116107
PubChem Substance ID:
329823204
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. N0950000
traceable to USP 1465004

API family

nitrofurazone

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

242-244 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NC(=O)N\N=C\c1ccc(o1)[N+]([O-])=O

InChI

1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+

InChI key

IAIWVQXQOWNYOU-FPYGCLRLSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Nitrofurazone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by DC polarography, chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0296 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1 - STOT RE 2

Target Organs

male reproductive organs

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Electrochemical reduction of nitrofurazone and its determination in pharmaceutical dosage forms by Dc polarography
Mishra AK and Gode KD
Analyst, 110(11), 1373-1376 (1985)
Inclusion compounds in pharmaceutical analysis II: Assay of a cream following chemical dehydration
Hays SE and Grady LT
Journal of Pharmaceutical Sciences, 60(2), 295-298 (1971)
Fengyu Deng et al.
Molecular bioSystems, 8(5), 1446-1451 (2012-02-18)
The interaction of nitrofurazone (NF) and human serum albumin (HSA) has been studied by fluorescence spectroscopy, FT-IR spectroscopy and molecular modeling methods. The results showed that the fluorescence of HSA was quenched by NF in a static quenching mechanism. Thermodynamic
James R Johnson et al.
Antimicrobial agents and chemotherapy, 56(9), 4969-4972 (2012-07-04)
Two marketed antimicrobial-coated Foley catheters were compared for in vitro diffusible and contact-dependent inhibition of 11 urinary tract infection-associated microorganisms in an adherence-biofilm assay. Nitrofurazone-coated catheters significantly outperformed silver alloy-coated catheters for inhibitory activity, according to both inoculum broth and
Hamid R Moghimi et al.
International journal of pharmaceutics, 401(1-2), 47-50 (2010-09-22)
Microwaves (MW), a part of the electromagnetic spectrum at 0.3-300GHz, affect human body in different ways through its thermal and athermal effects, including fluidization of cell membranes and liquid crystalline systems. Due to presence of such structures in skin barrier
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