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Merck
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PHR1154

Tributyl citrate

Pharmaceutical Secondary Standard; Certified Reference Material

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About This Item

Empirical Formula (Hill Notation):
C18H32O7
CAS Number:
77-94-1
Molecular Weight:
360.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823172
EC Number:
201-071-2
Beilstein/REAXYS Number:
1806072
MDL number:
MFCD00027217

Key Documents

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InChI key

ZFOZVQLOBQUTQQ-UHFFFAOYSA-N

InChI

1S/C18H32O7/c1-4-7-10-23-15(19)13-18(22,17(21)25-12-9-6-3)14-16(20)24-11-8-5-2/h22H,4-14H2,1-3H3

SMILES string

CCCCOC(=O)CC(O)(CC(=O)OCCCC)C(=O)OCCCC

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1680608

API family

tributyl acetylcitrate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.445

density

1.043 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Tributyl citrate is an ester of citric acid. It is used to plasticize polymers for coating solid drug dosage forms, tablets and capsules.


Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8989 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Handbook of Pharmaceutical Excipients, 1 (2006)
Bernadette Pretzl et al.
Journal of clinical periodontology, 36(4), 349-356 (2009-05-12)
Evaluation of the 10-year results after GTR-therapy of infrabony defects using two bioabsorbable barriers in a randomized-controlled clinical trial. In 15 patients with periodontitis, 15 pairs of infrabony defects were treated. For each patient, one defect received a polydioxanon (test:
Eva Roblegg et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 79(3), 635-645 (2011-08-02)
The objective of this study was the development of retarded release pellets using vegetable calcium stearate (CaSt) as a thermoplastic excipient. The matrix carrier was hot melt extruded and pelletized with a hot-strand cutter in a one step continuous process.
P Eickholz et al.
Journal of periodontology, 71(6), 999-1008 (2000-07-29)
The aim of this study was to compare the effects of guided tissue regeneration (GTR) using 2 different bioabsorbable barriers (control: polylactide acetyltributyl citrate; test: polydioxanon). The polydioxanon barrier is an experimental membrane for GTR therapy that consists of a
Werner Schroth et al.
Marine biotechnology (New York, N.Y.), 7(5), 449-461 (2005-06-25)
We describe a strategy that identifies molecular biomarkers and links the study of abiotic stress to evolutionary history. By utilizing the moon jellyfish Aurelia spp. as a model, we identified genes differentially regulated in response to the chemical stressor tributyltin
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