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PHR1152

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Phenyl salicylate melting point standard

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Phenyl salicylate, Salol
Linear Formula:
2-(HO)C6H4CO2C6H5
CAS Number:
118-55-8
Molecular Weight:
214.22
Beilstein:
393969
EC Number:
204-259-2
MDL number:
MFCD00002213
UNSPSC Code:
41116107
PubChem Substance ID:
329823170
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1534209

API family

phenyl salicylate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

172-173 °C/12 mmHg (lit.)

mp

~Approximately 42 °C
41-43 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Oc1ccccc1C(=O)Oc2ccccc2

InChI

1S/C13H10O3/c14-12-9-5-4-8-11(12)13(15)16-10-6-2-1-3-7-10/h1-9,14H

InChI key

ZQBAKBUEJOMQEX-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Phenyl salicylate is a phenyl ester of salicylic acid and is used as a medicine under the name ′salol′ as an internal antiseptic. It finds its application in paints, waxes, and varnishes as it is found to absorb UV radiation in the range of 290-325 nm. It also shows its presence in cosmetics and sunscreens as a UV filter.

Application

Phenyl salicylate may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7176 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H317,H319,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

WGK

WGK 2

Flash Point(F)

230.0 °F

Flash Point(C)

110 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An examination of the thermodynamics of fusion, vaporization, and sublimation of several parabens by correlation gas chromatography
Umnahanant P and Chickos J
Journal of Pharmaceutical Sciences, 100(5), 1847-1855 (2011)
Use of 1H NMR to facilitate solubility measurement for drug discovery compounds
Lin M, et al.
International Journal of Pharmaceutics, 369(1-2), 47-52 (2009)
Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity
Jimenez-Diaz I, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 936(6), 80-87 (2013)
Selective synthesis of phenyl salicylate (salol) by esterification reaction over solid acid catalysts
Kuriakose G and Nagaraju N
J. Mol. Catal. A: Chem., 223(1-2), 155-159 (2004)
Chemical analysis and ecotoxicological effects of organic UV-absorbing compounds in aquatic ecosystems
Diaz-Cruz MS and Barcelo Damia
TrAC, Trends in Analytical Chemistry, 28(6), 708-717 (2009)
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