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PHR1133

Cetyl Alcohol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1-Hexadecanol, Cetyl alcohol, Palmityl alcohol

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About This Item

Linear Formula:
CH3(CH2)15OH
CAS Number:
36653-82-4
Molecular Weight:
242.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823153
EC Number:
253-149-0
Beilstein/REAXYS Number:
1748475
MDL number:
MFCD00004760

Key Documents

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Product Name

Cetyl Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3

InChI key

BXWNKGSJHAJOGX-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCCCCCO

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. C0990000
traceable to USP 1103003

vapor density

8.34 (vs air)

vapor pressure

<0.01 mmHg ( 43 °C)

API family

cetyl alcohol

CofA

current certificate can be downloaded

autoignition temp.

483 °F

expl. lim.

8 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

179-181 °C/10 mmHg (lit.)

mp

48-50 °C (lit.)

density

0.818 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Cetyl Alcohol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7153 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

338.0 °F

flash_point_c

170 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The application of chromatography to the analysis of pharmaceutical creams.
Van de Vaart FJ, et al.
Chromatographia, 16(1), 247-250 (1982)
HPLC-fluorescence determination of chlorocresol and chloroxylenol in pharmaceuticals.
Gatti R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 16(3), 405-412 (1997)
Eddy Castellanos Gil et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(1), 303-311 (2007-12-07)
A novel oral controlled delivery system for propranolol hydrochloride (PPL) was developed and optimized using wet granulation process. We are studying the ability of subcoating with Kollidon VA 64 as a barrier to water penetration in matrix cores combined hydrophilic
Daniel Wehrung et al.
Colloids and surfaces. B, Biointerfaces, 94, 259-265 (2012-03-06)
The main objective of the study is to investigate the efficacy of Gelucire 44/14 (gelucire) in facilitating formation of cetyl alcohol (CA)-based nanoparticle (NP) and to assess the effects on key NP properties and functions. NPs from oil-in-water nanoemulsion precursors
Maria K Ratajczak et al.
Biophysical journal, 93(6), 2038-2047 (2007-05-29)
Adding cholesterol to monolayers of certain phospholipids drives the separation of liquid-ordered from liquid-disordered domains. The ordered phases appear to contain stoichiometric complexes of cholesterol and phospholipid. Furthermore, it has been suggested that the cholesterol in these complexes has a
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