Skip to Content
Merck
CN

PHR1127

Amoxicillin trihydrate

Pharmaceutical Secondary Standard; Certified Reference Material

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C16H19N3O5S · 3H2O
CAS Number:
61336-70-7
Molecular Weight:
419.45
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823148
MDL number:
MFCD00072029
Beilstein/REAXYS Number:
7507120

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Amoxicillin trihydrate, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1

SMILES string

O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O

InChI key

MQXQVCLAUDMCEF-CWLIKTDRSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. A0800000
traceable to USP 1031503

API family

amoxicillin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Amoxicillin trihydrate may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using liquid chromatography technique and spectrophotometric technique.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Amoxicillin trihydrate is a oral semisynthetic penicillin, which shows antibacterial activity against Gram positive and and a limited range of Gram-negative organisms. Its mode of action involves the inhibition of bacterial cell wall synthesis.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB3723 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Validated stability-indicating LC method for estimation of amoxicillin trihydrate in pharmaceutical dosage forms and time-dependent release formulations
Beg S, et al.
International Journal of Pharmaceutical Sciences and Nanotechnology, 4(2) (2011)
Spectrophotometric determination of amoxicillin in pharmaceutical formulations
Unal K, et al.
Turkish Journal of Pharmaceutical Sciences, 5(1), 1-16 (2008)
Qian Zhao et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(7), 1605-1611 (2013-04-05)
This paper investigated the effects of selected common chemical species in natural waters (HCO3(-), NO3(-) and humic acids (HA)) on the photodegradation of amoxicillin (AMO) under simulated irradiation using a 300 W xenon lamp. Quenching experiments were carried out to
Fanny B Morel et al.
Neonatology, 103(3), 182-189 (2013-02-26)
It is suggested that antibiotherapy in infancy might program adult body composition and thus could be a determinant of obesity risk. Although not convincingly substantiated by existing literature, this assumption is plausible since antibiotics affect intestinal microbiota, whose composition in
Yu-Hsin Lin et al.
Biomaterials, 34(18), 4466-4479 (2013-03-19)
Helicobacter pylori is a significant human pathogen that recognizes specific carbohydrate receptors, such as the fucose receptor, and produces the vacuolating cytotoxin, which induces inflammatory responses and modulates the cell-cell junction integrity of the gastric epithelium. The clinical applicability of
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service