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PHR1126

Sulfamethoxazole

Name: Sulfamethoxazole
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, N¹-(5-Methylisoxazol-3-yl)sulfanilamide

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁N₃O₃S

CAS Number:

723-46-6

Molecular Weight:

253.28

Beilstein:

6732984

EC Number:

211-963-3

MDL number:

MFCD00010546

UNSPSC Code:

41116107

PubChem Substance ID:

329823147

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 314
traceable to Ph. Eur. S2100000
traceable to USP 1631001

API family

sulfamethoxazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1

InChI

1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)

InChI key

JLKIGFTWXXRPMT-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Chromatography Standards

Pharmacopeia & Metrological Institute Standards

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Sulfamethoxazole is one of the most effective sulfa drugs used for treating urinary infections in humans.

Application

Sulfamethoxazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by square-wave voltammetry, and visible/UV spectrophotometry.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6910 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H361fd,H411

Precautionary Statements

P202 - P273 - P280 - P308 + P313 - P391 - P405

Hazard Classifications

Aquatic Chronic 2 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

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Determination of sulfamethoxazole and trimethoprim in pharmaceuticals by visible and UV spectrophotometry.

Shamsa F and Amani L

Iranian Journal of Pharmaceutical Research : IJPR, 31-36 (2010)

Electroanalytical determination of sulfadiazine and sulfamethoxazole in pharmaceuticals using a boron-doped diamond electrode.

Souza CD, et al.

Sensors and Actuators B, Chemical, 135(1), 66-73 (2008)

Impact of humic acid fouling on membrane performance and transport of pharmaceutically active compounds in forward osmosis.

Ming Xie et al.

Water research, 47(13), 4567-4575 (2013-06-15)

The impact of humic acid fouling on the membrane transport of two pharmaceutically active compounds (PhACs) - namely carbamazepine and sulfamethoxazole - in forward osmosis (FO) was investigated. Deposition of humic acid onto the membrane surface was promoted by the

Sorption of antibiotic sulfamethoxazole varies with biochars produced at different temperatures.

Hao Zheng et al.

Environmental pollution (Barking, Essex : 1987), 181, 60-67 (2013-07-03)

Sorption of sulfonamides on biochars is poorly understood, thus sulfamethoxazole (SMX) sorption on biochars produced at 300-600 °C was determined as a function of pH and SMX concentration, as well as the inorganic fractions in the biochars. Neutral SMX molecules

Trimethoprim-sulfamethoxazole-associated aseptic meningitis: case reports and review of the literature.

A M Joffe et al.

The American journal of medicine, 87(3), 332-338 (1989-09-01)

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