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PHR1089

Cimetidine hydrochloride

Name: Cimetidine hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₆N₆S · HCl

CAS Number:

70059-30-2

Molecular Weight:

288.80

Beilstein:

5668216

EC Number:

274-297-2

MDL number:

MFCD01724314

UNSPSC Code:

41116107

PubChem Substance ID:

329823111

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. C2175500
traceable to USP 1134073

API family

cimetidine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CN\C(NC#N)=N/CCSCc1nc[nH]c1C

InChI

1S/C10H16N6S.ClH/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11;/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);1H

InChI key

QJHCNBWLPSXHBL-UHFFFAOYSA-N

Gene Information

human ... HRH2(3274)

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General description

Cimetidine is a histamine H2-receptor antagonist, widely used to inhibit gastric acid secretion. It finds application in the treatment of gastric and duodenal ulcers.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Cimetidine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical preparations using gas chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7168 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.

Description

Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

LRAC0909

LRAA7168

P500089

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GC Determination of famotidine, ranitidine, cimetidine, and metformin in pharmaceutical preparations and serum using methylglyoxal as derivatizing reagent

Majidano AS, et al.

Chromatographia, 75(21-22), 1311-1317 (2012)

Effect of cimetidine on pentamidine induced hyperglycemia in rats.

Toru Arino et al.

European journal of pharmacology, 693(1-3), 72-79 (2012-09-13)

The antiprotozoal agent pentamidine, used for the treatment of Pneumocystis jirovecii pneumonia (PCP), is known to cause abnormalities in blood glucose homeostasis, such as hypoglycemia and hyperglycemia. Pentamidine has been reported to be a substrate of organic cation transporter 1

Clinical effects of psychological intervention and drug therapy against peptic ulcer.

Duo-Yu Wu et al.

Asian Pacific journal of tropical medicine, 5(10), 831-833 (2012-10-10)

To evaluate the clinical effects of psychological interventions and drug therapy against peptic ulcer. 96 patients with peptic ulcer were divided into control group with Tagamet 800 mg per evening p.o. and trial group with psychological intervention on the basis

Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells.

Yisheng Zheng et al.

Molecular immunology, 54(1), 74-83 (2012-12-12)

Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine

Homopterocarpin contributes to the restoration of gastric homeostasis by Pterocarpus erinaceus following indomethacin intoxication in rats.

M Tolulope Olaleye et al.

Asian Pacific journal of tropical medicine, 6(3), 200-204 (2013-02-05)

To investigate the restorative effect of Pterocarpus erinaceus (P. erinaceus) and homopterocarpin, an isoflavonoid isolated from it, on indomethacin-induced disruption in gastric homeostasis in rats. Adult rats were divided into five groups and fasted for 48 h before treatment. Group

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