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PHR1085

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Homosalate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

3,3,5-Trimethylcyclohexyl salicylate, 2-Hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester, Homomenthyl salicylate, Homosalate

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About This Item

Empirical Formula (Hill Notation):
C16H22O3
CAS Number:
118-56-9
Molecular Weight:
262.34
Beilstein:
2731604
EC Number:
204-260-8
MDL number:
MFCD00019377
UNSPSC Code:
41116107
PubChem Substance ID:
329823107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1311408

API family

homosalate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CC1CC(CC(C)(C)C1)OC(=O)c2ccccc2O

InChI

1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3

InChI key

WSSJONWNBBTCMG-UHFFFAOYSA-N

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General description

Homosalate is a UV filter that protects the skin from the harmful effects of UVB (280-315 nm) and UVA II (315-340 nm) radiations. It is widely utilized in make-up, sunscreen and topical formulations.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Homosalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3174 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Certificates of Analysis (COA)

Lot/Batch Number
LRAD7941
LRAD4593
LRAD4810
LRAC9157
LRAC8695

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Supercritical fluid extraction and high performance liquid chromatography determination of homosalate in lipsticks
Salvador A, et al.
Chromatographia, 54(11-12), 795-797 (2001)
Homosalate
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 37(2), 2163-2163 (2013)
E Chatelain et al.
Skin pharmacology and applied skin physiology, 16(1), 28-35 (2003-02-05)
To gain information about efficacy and safety of sunscreens, we compared the skin penetration of ultraviolet (UV) filters from two vehicles, i.e. an oil-in-water (O/W) emulsion gel and petrolatum jelly both in vitro and in vivo, as well as the
Comments on "In vitro and in vivo estrogenicity of UV screens".
H M Bolt et al.
Environmental health perspectives, 109(8), A358-A361 (2001-09-21)
Yufeng Zhang et al.
Journal of chromatography. A, 1271(1), 56-61 (2012-12-15)
In the present study, a rapid, highly efficient and environmentally friendly sample preparation method named temperature-controlled ionic liquid dispersive liquid-phase microextraction (TC-IL-DLPME), followed by high performance liquid chromatography (HPLC) was developed for the extraction, preconcentration and determination of four benzophenone-type
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