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PHR1083

Supelco

Octocrylene

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Ethylhexyl 2-cyano-3,3-diphenylacrylate, OC

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About This Item

Linear Formula:
(C6H5)2C=C(CN)CO2CH2CH(C2H5)(CH2)3CH3
CAS Number:
6197-30-4
Molecular Weight:
361.48
EC Number:
228-250-8
MDL number:
MFCD00059260
UNSPSC Code:
41116107
PubChem Substance ID:
329823105
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1477411

API family

octocrylene

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.567 (lit.)

bp

218 °C/1.5 mmHg (lit.)

mp

−10 °C (lit.)

density

1.051 g/mL at 25 °C (lit.)

application(s)

environmental
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCCC(CC)COC(=O)\C(C#N)=C(/c1ccccc1)c2ccccc2

InChI

1S/C24H27NO2/c1-3-5-12-19(4-2)18-27-24(26)22(17-25)23(20-13-8-6-9-14-20)21-15-10-7-11-16-21/h6-11,13-16,19H,3-5,12,18H2,1-2H3

InChI key

FMJSMJQBSVNSBF-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Octocrylene may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0433 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

WGK

WGK 2

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD5337
LRAD7913
LRAD3300
LRAD2582
LRAC0433

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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The difficulties for a photolabile drug in topical formulations: The case of diclofenac
Ioele G, et al.
International Journal of Pharmaceutics, 465(1-2), 284-290 (2014)
Lucie Duracher et al.
Photochemistry and photobiology, 85(6), 1459-1467 (2009-08-07)
Increasing legal requirements for risk assessment and efficacy testing in the dermo-cosmetic field have led to the development of alternative test methods. In this study, the porcine skin model was chosen to test the effect of irradiation on the penetration
Weihong Li et al.
Water research, 41(15), 3506-3512 (2007-06-29)
Four UV filters, benzophenone-3 (BP-3), 4-methylbenzylidence camphor (4-MBC), ethylhexyl methoxycinnamate (EHMC), and octocrylene (OC), have been examined along the different units of a wastewater reclamation plant (WWRP) located in Tianjin, North China. The analytical procedure included solid-phase extraction and gas
Rosario Rodil et al.
Journal of chromatography. A, 1179(2), 81-88 (2007-12-22)
Stir bar sorptive extraction (SBSE) in combination with thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) was applied for the determination of 9 UV filters in water samples. The stir bar coated with polydimethylsiloxane (PDMS) was added to 20 mL of water sample
N Negreira et al.
Analytical and bioanalytical chemistry, 400(2), 603-611 (2011-02-22)
This work describes an effective, low solvent consumption and affordable sample preparation approach for the determination of eight UV filters in surface and wastewater samples. It involves sorptive extraction of target analytes in a disposable, technical grade silicone disc (5 mm
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