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Octisalate

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
2-Ethylhexyl salicylate, Octisalate, Octyl salicylate
Linear Formula:
(HO)C6H4CO2CH2CH(C2H5)(CH2)3CH3
CAS Number:
118-60-5
Molecular Weight:
250.33
Beilstein:
2730664
EC Number:
204-263-4
MDL number:
MFCD00053300
UNSPSC Code:
41116107
PubChem Substance ID:
329823104
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1477943

API family

octisalate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.502 (lit.)

bp

189-190 °C/21 mmHg (lit.)

density

1.014 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCCC(CC)COC(=O)c1ccccc1O

InChI

1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

InChI key

FMRHJJZUHUTGKE-UHFFFAOYSA-N

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General description

Octisalate is a sunscreen agent that acts as a UV filter for UVB (280-315 nm) radiation.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Octisalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical and sunscreen formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0298 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Chronic 1

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Octisalate
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 43(3), 3194-3194 (2018)
Thin layer chromatography-spray mass spectrometry: a method for easy identification of synthesis products and UV filters from TLC aluminum foils
Himmelsbach M, et al.
Analytical and Bioanalytical Chemistry, 406(15), 3647-3656 (2014)
P Clarys et al.
Journal of dermatological science, 27(2), 77-81 (2001-09-05)
Temperature influences the stratum corneum adsorption of several topically applied compounds. This study was designed to evaluate the influence of the temperature on the stratum corneum adsorption of 3 UV filters. The UV filters were solubilized in two vehicles, an
Beatriz Albero et al.
Journal of chromatography. A, 1248, 9-17 (2012-06-12)
The determination of organic contaminants in soil is a real challenge due to the large number of these compounds with quite different physico-chemical properties. In the present work, an analytical method was developed for the simultaneous determination in soil of
K A Walters et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 35(12), 1219-1225 (1998-02-04)
The human skin penetration of [14C]octyl salicylate from two representative sunscreen vehicles was determined in vitro. 3H-sucrose was incorporated into all formulations and provided a marker for membrane integrity. When applied as a finite dose in an oil-in-water emulsion vehicle
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