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PHR1059

Omeprazole

Name: Omeprazole
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉N₃O₃S

CAS Number:

73590-58-6

Molecular Weight:

345.42

MDL number:

MFCD00083192

UNSPSC Code:

41116107

PubChem Substance ID:

329823089

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 765
traceable to Ph. Eur. O0150000
traceable to USP 1478505

API family

omeprazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C

InChI

1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChI key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Chromatography Standards

Controlled Substances & Illicit Drug Standards

Pharmacopeia & Metrological Institute Standards

General description

Omeprazole is a benzimidazole drug, which exhibits antisecretory and antiulcer properties. It is widely used in the treatment of duodenal, gastric ulcers, reflux oesophagitis and against other acid-related diseases.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Omeprazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique and high-performance liquid chromatography technique.

Omeprazole may be used as a reference standard in the determination of omeprazole in pharmaceutical formulations using high performance thin layer chromatography (HPTLC).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0716 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H317,H411

Precautionary Statements

P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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A validated HPTLC method for determination of ondansetron in combination with omeprazole or rabeprazole in solid dosage form

Raval.B.P, et al.

Indian Journal of Pharmaceutical Sciences, 70(3), 386-386 (2008)

Spectrophotometric determination of omeprazole, lansoprazole and pantoprazole in pharmaceutical formulations

Wahbi AAM, et al.

Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1133-1142 (2002)

Extractive spectrophotometric determination of omeprazole in pharmaceutical preparations

Bhandage A, et al.

Tropical Journal of Pharmaceutical Research, 8(5), 1133-1142 (2009)

A validated normal phase HPLC method for simultaneous determination of drotaverine hydrochloride and omeprazole in pharmaceutical formulation

Topagi SK, et al.

Asian Journal of Pharmaceutical and Clinical Research, 3(1), 20-24 (2010)

Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.

Kazuhiro Shiizaki et al.

Molecular pharmacology, 85(2), 279-289 (2013-11-23)

Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While

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