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PHR1058

Clotrimazole

Name: Clotrimazole
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₇ClN₂

CAS Number:

23593-75-1

Molecular Weight:

344.84

EC Number:

245-764-8

MDL number:

MFCD00057220

UNSPSC Code:

41116107

PubChem Substance ID:

329823088

NACRES:

NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 379
traceable to Ph. Eur. C2430000
traceable to USP 1141002

API family

clotrimazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

InChI key

VNFPBHJOKIVQEB-UHFFFAOYSA-N

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Related Categories

Analytical Reference Standards

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clotrimazole is an imidazole antifungal agent with relatively low toxicity. It is widely used in dermatology and gynaecology applications. Clotrimazole ointments are extensively utilized for the treatment of a wide range of systemic mycoses including candidiasis.

Application

Clotrimazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7129 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.

Description

Pricing

1141024

PHR2700

PHR3005

Clotrimazole Impurity F, pharmaceutical secondary standard, certified reference material

Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H315,H319,H410

Precautionary Statements

P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 3

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Development and validation of HPLC method for determination of clotrimazole and its two degradation products in spray formulation

Hajkova R, et al.

Talanta, 73(3), 483-489 (2007)

Determination of methylparaben, propylparaben, clotrimazole and its degradation products in topical cream by RP-HPLC

Solich P, et al.

Chromatographia, 56(1), S181-S184 (2002)

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.

Sandra Gemma et al.

Journal of medicinal chemistry, 55(15), 6948-6967 (2012-07-13)

Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development of a novel antimalarial drug that combines the 4-aminoquinoline pharmacophore of

The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.

Barbara A Miller et al.

American journal of physiology. Heart and circulatory physiology, 304(7), H1010-H1022 (2013-02-05)

The second member of the transient receptor potential-melastatin channel family (TRPM2) is expressed in the heart and vasculature. TRPM2 channels were expressed in the sarcolemma and transverse tubules of adult left ventricular (LV) myocytes. Cardiac TRPM2 channels were functional since

Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death.

Michael B McFerrin et al.

American journal of physiology. Cell physiology, 303(10), C1070-C1078 (2012-09-21)

An important event during apoptosis is regulated cell condensation known as apoptotic volume decrease (AVD). Ion channels have emerged as essential regulators of this process mediating the release of K(+) and Cl(-), which together with osmotically obliged water, results in

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