PHR1051
Propylene glycol
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
1,2-Propanediol, Propylene glycol
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About This Item
Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
Molecular Weight:
76.09
Beilstein:
1340498
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
E Number:
E1520
NACRES:
NA.24
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to USP 1576708
vapor density
2.62 (vs air)
vapor pressure
0.08 mmHg ( 20 °C)
API family
propylene glycol
CofA
current certificate can be downloaded
autoignition temp.
779 °F
expl. lim.
12.5 %
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.432 (lit.)
bp
187 °C (lit.)
mp
−60 °C (lit.)
density
1.036 g/mL at 25 °C (lit.)
application(s)
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
CC(O)CO
InChI
1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3
InChI key
DNIAPMSPPWPWGF-UHFFFAOYSA-N
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propylene glycol is commonly utilized as a penetration enhancer in topical dermatological formulations, either alone or in combined form with other penetration enhancing agents, like fatty acids.
Propylene glycol is commonly utilized as a penetration enhancer in topical dermatological formulations, either alone or in combined form with other penetration enhancing agents, like fatty acids.
Application
Propylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAB9658 in the slot below. This is an example certificate only and may not be the lot that you receive.
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Analysis of aldehydes in excipients used in liquid/semi-solid formulations by gas chromatography-negative chemical ionization mass spectrometry
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Journal of Chromatography A, 1160(1-2), 299-305 (2007)
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International Journal of Pharmaceutics, 274(1-2), 213-219 (2004)
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