PHR1044
Ciprofloxacin HCl
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Ciprofloxacin hydrochloride monohydrate
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About This Item
Empirical Formula (Hill Notation):
C17H18FN3O3 · HCl · H2O
CAS Number:
Molecular Weight:
385.82
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to BP 929
traceable to Ph. Eur. C2190000
traceable to USP 1134335
API family
ciprofloxacin
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
O.Cl.OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O
InChI
1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2
InChI key
ARPUHYJMCVWYCZ-UHFFFAOYSA-N
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General description
Ciprofloxacin HCl is a fluoroquinolone antibiotic agent, which shows a broad spectrum of antibacterial activity against gram positive and gram negative bacteria.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ciprofloxacin is grouped under the class of second generation of quinolone analogs of nalidixic acid that exhibits high potency, minimal toxicity and a broad-spectrum antibacterial activity. It can be administered both parenterally and orally. It finds applications in the treatment of broad range of infections of the urinary tract, respiratory tract and gastrointestinal tract, as well as skin and soft tissue infections.
Ciprofloxacin is grouped under the class of second generation of quinolone analogs of nalidixic acid that exhibits high potency, minimal toxicity and a broad-spectrum antibacterial activity. It can be administered both parenterally and orally. It finds applications in the treatment of broad range of infections of the urinary tract, respiratory tract and gastrointestinal tract, as well as skin and soft tissue infections.
Application
Ciprofloxacin HCl has been used as a test compound in combination with the high-throughput nanowell antibiotic susceptibility testing device to validate its effectiveness as an antibacterial agent, thereby preventing the growth of bacteria. It may also be used as a standard in the determination of ciprofloxacin HCl in pharmaceutical preparations and serum samples using reversed-phase high performance liquid chromatography (RP-HPLC).
Ciprofloxacin HCl may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography and chemiluminescence detection.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAB3671 in the slot below. This is an example certificate only and may not be the lot that you receive.
related product
Product No.
Description
Pricing
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Simultaneous determination of ciprofloxacin hydrochloride and dexamethasone sodium phosphate in eye drops by HPLC
Katakam P and Sireesha KR
Journal of Chemistry, 9(3), 1077-1084 (2012)
Bacterial nanoscale cultures for phenotypic multiplexed antibiotic susceptibility testing
Weibull E, et al.
Journal of Clinical Microbiology, 52(9), 3310- 3317 (2014)
Chemiluminescence determination of some fluoroquinolone derivatives in pharmaceutical formulations and biological fluids using [Ru (bipy)32+]-Ce (IV) system
Aly FA, et al.
Talanta, 53(4), 885-893 (2001)
Łukasz Szczupak et al.
Dalton transactions (Cambridge, England : 2003), 49(5), 1403-1415 (2019-12-19)
The synthesis, characterization and biological activity of six bioorganometallic conjugates of ciprofloxacin with ferrocenyl, ruthenocenyl and cymantrenyl entities are described. Their antimicrobial activities were investigated against Gram-positive bacteria, Gram-negative bacteria and bloodstream forms of Trypanosoma brucei. Furthermore, the morphological changes
H Maertens et al.
BMC microbiology, 20(1), 155-155 (2020-06-13)
Quaternary ammonium compound based disinfectants are commonly used in pig and poultry husbandry to maintain farm hygiene. However, studies have shown that subinhibitory concentrations of these disinfectants may increase antibiotic resistance. Investigation of antibiotic susceptibility is usually assessed via the
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