Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

PHR1014

Supelco

Hydrocortisone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
50-23-7
Molecular Weight:
362.46
Beilstein:
1354819
EC Number:
200-020-1
MDL number:
MFCD00011654
UNSPSC Code:
41116107
PubChem Substance ID:
329823045
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 576
traceable to Ph. Eur. H1300000
traceable to USP 1316004

API family

hydrocortisone

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

211-214 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone is a degradation product of the corticosteroid, hydrocortisone acetate.

Application

Hydrocortisone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3713 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

1316004

Hydrocortisone, United States Pharmacopeia (USP) Reference Standard

1317007

Hydrocortisone acetate, United States Pharmacopeia (USP) Reference Standard

1317302

Hydrocortisone butyrate, United States Pharmacopeia (USP) Reference Standard

1319002

Hydrocortisone hemisuccinate, United States Pharmacopeia (USP) Reference Standard

H1400000

Hydrocortisone acetate, European Pharmacopoeia (EP) Reference Standard

H1300000

Hydrocortisone, European Pharmacopoeia (EP) Reference Standard

H1425000

Hydrocortisone hydrogen succinate, European Pharmacopoeia (EP) Reference Standard

Y0001092

Hydrocortisone for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0001482

Hydrocortisone acetate for peak identification, European Pharmacopoeia (EP) Reference Standard

1321004

Hydrocortisone valerate, United States Pharmacopeia (USP) Reference Standard

1320001

Hydrocortisone phosphate triethylamine, United States Pharmacopeia (USP) Reference Standard

BP576

Hydrocortisone, British Pharmacopoeia (BP) Assay Standard

PHR1606

Hydrocortisone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

BP584

Hydrocortisone acetate, British Pharmacopoeia (BP) Reference Standard

BP187

Hydrocortisone hydrogen succinate, British Pharmacopoeia (BP) Reference Standard

PHR1926

Hydrocortisone Hemisuccinate, Pharmaceutical Secondary Standard; Certified Reference Material

BP188

Hydrocortisone sodium phosphate, British Pharmacopoeia (BP) Reference Standard

PHR2160

Hydrocortisone Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2157

Hydrocortisone Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2162

Hydrocortisone Impurity L, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2161

Hydrocortisone Impurity K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2159

Hydrocortisone Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2163

Hydrocortisone Impurity M, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2158

Hydrocortisone Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2164

6a-Hydroxyhydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2156

Hydrocortisone Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3185

Hydrocortisone Valerate, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360Df,H373

Hazard Classifications

Repr. 1A - STOT RE 2

Target Organs

Adrenal gland,Bone marrow

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD4806
LRAD1246
LRAC5168
LRAB3713
P500014

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Simultaneous determination of hydrocortisone and benzyl alcohol in pharmaceutical formulations by reversed-phase high-pressure liquid chromatography.
Rego Aand Nelson B
Journal of Pharmaceutical Sciences, 71(11), 1219-1223 (1982)
Advantages of application of UPLC in pharmaceutical analysis.
Novakova L, et al.
Talanta, 68(3), 908-918 (2006)
On-line post-column photochemical derivatization in liquid chromatographic− diode-array detection analysis of binary drug mixtures.
Di Pietra AM,et al
Journal of Pharmaceutical and Biomedical Analysis, 14(8-10), 1191-1199 (1996)
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)
Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service