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Merck
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P9672

Probucol

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C31H48O2S2
CAS Number:
23288-49-5
Molecular Weight:
516.84
NACRES:
NA.24
PubChem Substance ID:
329820354
UNSPSC Code:
41116107
EC Number:
245-560-9
MDL number:
MFCD00079281

Key Documents

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Product Name

Probucol, analytical standard

InChI key

FYPMFJGVHOHGLL-UHFFFAOYSA-N

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

SMILES string

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

200

Gene Information

human ... ABCA1(19), IL1B(3553), IL6(3569), TNF(7124)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Enhances selective uptake of HDL-associated cholesteryl esters.

General description

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000512647
0000512647
0000492794
0000492794
0000460435

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Atherosclerosis: Treatment and Prevention (2012)
Miwako Inagaki et al.
Journal of atherosclerosis and thrombosis, 19(7), 643-656 (2012-07-13)
High density lipoprotein (HDL) has multi-antiatherogenic effects such as antioxidation and anti-inflammation, in addition to being a key mediator of reverse cholesterol transport. Probucol, known as a lipid lowering drug, is also a potent antioxidant, but it decreases serum HDL
Zhiwen Zhang et al.
International journal of pharmaceutics, 444(1-2), 162-168 (2013-01-24)
The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics (2013)
Eduardo Luiz Gasnhar Moreira et al.
Neuroscience letters, 541, 193-198 (2013-03-09)
Epidemiological studies indicate that high midlife plasma cholesterol levels increases the risk of Alzheimer's disease. Moreover, middle-aged familial hypercholesterolemia (FH) subjects show a particularly high incidence of mild cognitive impairments (MCI). These evidence points to hypercholesterolemia as one of the
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Articles

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

胆固醇的运输

由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。

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