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P8136

Sigma-Aldrich

Poly(vinyl alcohol)

87-90% hydrolyzed, average mol wt 30,000-70,000

Synonym(s):

PVA, PVAl, PVOH, Poly(Ethenol)

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About This Item

Linear Formula:
[-CH2CHOH-]n
CAS Number:
9002-89-5
MDL number:
MFCD00081922
UNSPSC Code:
12352104
NACRES:
NA.21

Quality Level

200

form

powder

mol wt

average mol wt 30,000-70,000

viscosity

4-6 cP, 4 % in H2O(20 °C)(lit.)

solubility

H2O: soluble

InChI

1S/C2H4O/c1-2-3/h2-3H,1H2

InChI key

IMROMDMJAWUWLK-UHFFFAOYSA-N

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Application

Poly(vinyl alcohol) has been used:
  • in in vitro production (IVP) of bovine embryos
  • oocyte recovery and in vitro maturation
  • as a macromolecular component in basal cultured medium

Biochem/physiol Actions

Poly(vinyl alcohol) (PVA) is a polyhydroxy polymer, soluble in water. PVA is known to possess high mechanical strength, biocompatibility and non-toxicity. Hence, it serves as a biomedical implant material. Polymerization of vinyl acetate to poly (vinyl acetate), which is then hydrolysed to form PVA. Its application is observed in drug delivery systems, wound dressing, dialysis membranes, artificial skin, surgical repairs and cardiovascular devices.

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What does "87-90% hydrolyzed" mean?

    Polyvinyl alcohol is normally prepared by hydrolysis of the acetate, CH3(C=O)O, groups of polyvinylacetate, to leave behind the polyvinyl backbone with the OH groups.  The expected degree of acetate hydrolysis is 87-90%.  This means that 87-90% of the side groups are OH, while the remaining 10-13% side groups are CH3(C=O)O.

  6. What does "MALLS" mean on the Specification Sheet or Certificate of Analysis?

    MALLS stands for Multi-Angle Laser Light Scattering.  Sometimes now called Multiangle Light Scattering (MALS), this technique allows for the determination of a MW range and particle size range of a given species in solution.

  7. Can I sterile-filter a solution of this product?

    In general, PVA solutions are very viscous, and sterile-filtering would probably be quite difficult.  It might be better to coat the surface of interest and then irradiate the coated surface under UV light, such as in a cell culture hood.

  8. Can I use this product in cell culture work?

    We have not specifically tested P8136 for use with cultured cells.  This is also not a sterile product. However, several publications claim use of P8136 in culture work.

  9. What is the best way to prepare a solution of Product P8136, poly(vinyl alcohol)?

    Product P8136, poly(vinyl alcohol), should be solubilized in cold water with adequate agitation to ensure complete wetting of the particles. (That is, keep the particles suspended with gentle stirring.) The temperature should then be increased to 85°C for 30 minutes to ensure complete dissolution. Product P8136 has been found to be soluble in water at a concentration of 50 mg/mL, yielding a clear to slightly hazy, colorless to faint yellow solution.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Birth of Piglets Derived from Porcine Zygotes Cultured in a Chemically Defined Medium
Yoshioka K, et al.
Biology of Reproduction, 66(1), 112?119-112?119 (2002)
Structure and applications of poly (vinyl alcohol) hydrogels produced by conventional crosslinking or by freezing/thawing methods
Biopolymers PVA Hydrogels Anionic Polymerisation Nanocomposites, 37-65 (2000)
In Vitro Developmental Competence of In Vitro-Matured Bovine Oocytes Fertilized and Cultured in Completely Defined Media
Keskintepe L and Brackett BG
Biology of Reproduction, 55, 333-339 (1996)
C Wrenzycki et al.
Human reproduction (Oxford, England), 16(5), 893-901 (2001-05-02)
Assisted reproduction technologies have made great progress during the last 15 years in most mammalian species, including humans. Growing evidence indicates that bovine pre-implantation development is a superior model for investigating early human development than the mouse. The purpose of
Nanostructured poly(vinyl alcohol)/bioactive glass and poly(vinyl alcohol)/chitosan/bioactive glass hybrid scaffolds for biomedical applications
Mansur HS and Costa HS
Chemical Engineering Journal, 137, 72-83 (2008)
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