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Merck
CN

P5555

Puerarin

analytical standard

Synonym(s):

8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, Kakonein

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About This Item

Empirical Formula (Hill Notation):
C21H20O9
CAS Number:
3681-99-0
Molecular Weight:
416.38
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329820231
MDL number:
MFCD00076007
Beilstein/REAXYS Number:
64198

Key Documents

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InChI

1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)ccc3C(=O)C(=COc23)c4ccc(O)cc4

InChI key

HKEAFJYKMMKDOR-VPRICQMDSA-N

grade

analytical standard

assay

~80% (HPLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages
forensics and toxicology
veterinary

format

neat

Quality Level

100

Gene Information

mouse ... Aldh1a2(19378), Maoa(17161)

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Application

Puerarin may be used as a reference standard for the determination of puerarin in rat plasma after administration of puerariae radix isoflavone, using high performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ1813
MKCR7658
MKCN0894
WXBD0486V
MKCG6104

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HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone
Yan B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(2), 297-301 (2005)
Jeevan K Prasain et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(1), 17-23 (2012-11-06)
The incidence of type 2 diabetes and metabolic disease is rapidly increasing, but effective therapies for their prevention and treatment have been poorly tolerated or minimally effective. In this study, chronic administration of kudzu root extract (8 months, 0.2%, w/w
Hai-quan Tao et al.
Naunyn-Schmiedeberg's archives of pharmacology, 386(1), 61-70 (2012-11-30)
It is well known that puerarin attenuates ischemia-reperfusion injury and promotes function recovery of ischemic region. However, due to its reverse physiochemical properties, puerarin does not easily cross the blood-brain barrier. The aim of the present study is to create
Wen Cheng et al.
PloS one, 7(9), e45529-e45529 (2012-10-03)
Puerarin is a major isoflavonoid compound extracted from Radix puerariae. It has a weak estrogenic action by binding to estrogen receptors (ERs). In our early clinical practice to treat endometriosis, a better therapeutic effect was achieved if the formula of
Ka H Wong et al.
Journal of pharmaceutical and biomedical analysis, 84, 5-13 (2013-06-20)
The aims of the study were to differentiate Pueraria lobata from its related species Pueraria thomsonii and to examine the raw herbal material used in manufacturing kudzu root granules using partial least square discriminant analysis (PLS-DA). Sixty-four raw materials of
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