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P4722

Pyridoxine hydrochloride

Name: Pyridoxine hydrochloride
Brand: SIAL

meets USP testing specifications

Synonym(s):

Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B₆ hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₁NO₃ · HCl

CAS Number:

58-56-0

Molecular Weight:

205.64

Beilstein:

3632435

EC Number:

200-386-2

MDL number:

MFCD00012807

UNSPSC Code:

12352205

eCl@ss:

34058008

PubChem Substance ID:

24898493

NACRES:

NA.21

biological source

synthetic (organic)

Quality Level

200

Agency

USP/NF
meets USP testing specifications

Assay

98.0-102.0% dry basis

form

powder

color

white

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

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Related Categories

Coenzymes

Vitamins

General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. The food sources of vitamin B₆include grains, nuts, fruits, vegetables and meat.

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats. It has also been used as a reference standard to quantify vitamin B₆ in feed and digesta samples using high-performance liquid chromatography(HPLC).

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids. It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels. Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin. Pyridoxine in excess or deficient may lead to neuropathy.

Pictograms

GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Nutritional neuropathies

Hammond N, et al.

Neurologic Clinics, 31(2), 477-477 (2013)

B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

Calderon-Ospina CA, et al.

CNS Neuroscience & Therapeutics (2019)

Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat

Kuypers NJ and Hoane MR

Journal of Neurotrauma, 27(7), 1275-1282 (2010)

Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows

Castagnino DS, et al.

Journal of Dairy Science, 99(3), 1884-1894 (2016)

Vitamin B6 and its role in cell metabolism and physiology

Parra M, et al.

Cells, 7(7), 84-84 (2018)

View All Related Papers

Articles

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

Vitamin B6's impact on serum-free cell culture systems is explored for protein manufacturing.

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