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P2126

Sigma-Aldrich

L-Phenylalanine

≥98%

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Synonym(s):
(S)-2-Amino-3-phenylpropionic acid
Linear Formula:
C6H5CH2CH(NH2)CO2H
CAS Number:
63-91-2
Molecular Weight:
165.19
Beilstein:
1910408
EC Number:
200-568-1
MDL number:
MFCD00064227
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24898274
NACRES:
NA.26

grade

reagent grade

Quality Level

200

Assay

≥98%

form

powder or crystals

color

white to off-white

mp

270-275 °C (dec.) (lit.)

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

application(s)

detection

SMILES string

N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1

InChI key

COLNVLDHVKWLRT-QMMMGPOBSA-N

Gene Information

human ... CA1(759) , CA14(23632) , CA2(760) , CA4(762) , CA5A(763) , CA7(766)

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Application

L-Phenylalanine has been used in Fluo-4 Ca2+-assay in a study to demonstrate that G-protein coupled receptor 139 reference surrogate agonists 1a and 7c and L-phenylalanine share a common binding site. It has also been used to spike blood samples to study the effect of dried blood spots on newborn screening.

Biochem/physiol Actions

L-Phenylalanine is an essential aromatic amino acid. It has a role in metabolism as it forms a starting point for many pathways. This neutral amino acid is a precursor for tyrosine, epinephrine, dopamine and norepinephrine.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site
Anne Cathrine
Scientific Reports (2017)
AMINO ACIDS | Metabolism
Encyclopedia of Food and Color Additives, 197-206 (2003)
Effect of Dried Blood Spot Quality on Newborn Screening Analyte Concentrations and Recommendations for Minimum Acceptance Criteria for Sample Analysis
Roanna S. George, Stuart J. Moat
Clinical Chemistry (2016)
Protein and Amino Acid Metabolism
ESSENTIALS OF MEDICINAL CHEMISTRY null
Genetics in Medicine : Official Journal of the American College of Medical Genetics (2012)
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