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Key Documents

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Safety Information

P1004

Sigma-Aldrich

Polymyxin B sulfate salt

Synonym(s):

Polymixin, Polymixin B, Polymixin B sulfate

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200 μG
CN¥7,573.10

CN¥7,573.10

Estimated to ship onApril 21, 2025Details

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200 μG
CN¥7,573.10

About This Item

Empirical Formula (Hill Notation):
C55H96N16O13 · 2H2SO4
CAS Number:
1405-20-5
Molecular Weight:
1385.61
EC Number:
215-774-7
MDL number:
MFCD00131991
UNSPSC Code:
51283106
NACRES:
NA.76

CN¥7,573.10

Estimated to ship onApril 21, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZRB1625
Request a Bulk Order

biological source

Pseudomonas aeruginosa

Quality Level

200

form

powder

storage condition

(Tightly closed. Dry. )

solubility

water: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
fungi

Mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

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Show Differences

1 of 4

This Item
1617316233ABT135
抗 FAK 抗体，克隆 4.47 clone 4.47, Upstate®, from mouse

05537

抗 FAK 抗体，克隆 4.47

Anti-FAK Antibody, clone 4.47, agarose conjugate clone 4.47, Upstate®, from mouse

16173

Anti-FAK Antibody, clone 4.47, agarose conjugate

Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate clone 4.47, Upstate®, from mouse

16233

Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate

Anti-phospho-FAK (Tyr397) Antibody from rabbit, purified by affinity chromatography

ABT135

Anti-phospho-FAK (Tyr397) Antibody

biological source

mouse

biological source

mouse

biological source

mouse

biological source

rabbit

clone

4.47, monoclonal

clone

4.47, monoclonal

clone

4.47, monoclonal

clone

polyclonal

antibody form

purified immunoglobulin

antibody form

-

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

UniProt accession no.

Q05397

UniProt accession no.

Q05397

UniProt accession no.

Q05397

UniProt accession no.

Q05397

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

immunoprecipitation (IP): suitable

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, western blot: suitable

technique(s)

cell based assay: suitable, western blot: suitable

General description

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate.

Application

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Polymyxin B sulfate salt has been used:
  • in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin[1]
  • in the analysis of the isolates[2]
  • in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)[3]

Biochem/physiol Actions

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae[4].

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Preparation Note

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.

Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

Storage and Stability

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000435113
    0000435113
    0000412466
    0000412466
    0000419056

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Endotoxin-neutralizing activity and mechanism of action of a cationic alpha-helical antimicrobial octadecapeptide derived from alpha-amylase of rice
    Taniguchi M, et al.
    Peptides, 101-108 (2016)
    Xucheng Huang et al.
    International journal of medical microbiology : IJMM, 308(7), 819-828 (2018-07-24)
    Ureaplasma spp. are known to be associated with human genitourinary tract diseases and perinatal diseases and Ureaplasma spp. Lipid-associated membrane proteins (LAMPs) play important roles in their related diseases. However, the exact mechanism underlying pathogenesis of Ureaplasma spp. LAMPs is
    Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-kappaB/COX-2 signaling in human aortic endothelial cells
    Addabbo F, et al.
    American Journal of Physiology. Endocrinology and Metabolism, 301(6), E1143-E1143 (2011)
    Biochemical and toxic diversity of Bacillus cereus in a pasta and meat dish associated with a food-poisoning case
    Pirhonen T I, et al.
    Food Microbiology, 22(1), 87-91 (2005)
    Dosing and pharmacokinetics of polymyxin B in patients with renal insufficiency
    Thamlikitkul V, et al.
    Antimicrobial Agents and Chemotherapy, e01337-e01316 (2017)
    View All Related Papers

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