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Sigma-Aldrich

Oxacillin sodium salt monohydrate

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Linear Formula:
C19H18N3O5SNa · H2O
CAS Number:
Molecular Weight:
441.43
Beilstein:
4287093
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

form

powder

Quality Level

solubility

water: 50-52 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

[Na+].[H]O[H].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c3c(C)onc3-c4ccccc4)C([O-])=O

InChI

1S/C19H19N3O5S.Na.H2O/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

InChI key

ZVIYWUUZWWBNMB-VICXVTCVSA-M

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Application

Oxacillin sodium salt monohydrate has been used in penicillin (PEN) standards. In turbidimetric method, oxacillin sodium salt monohydrate has been used in the medium with antibiotic.

Biochem/physiol Actions

Oxacillin and its derivatives are released through urine with the help of glomerular filtration and tubular secretion. It can be used in nursing mothers. Oxacillin is used in the treatment of methicillin-susceptible S. aureus (MSSA) infections. It shows resistance to penicillinase.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Drugs and Lactation Database (LactMed) (2006)
The Washington Manual Infectious Diseases Subspecialty Consult, 352-352 (2005)
An easy-to-use, rapid and inexpensive method to determine methicillin resistance in Staphylococcus aureus.
Gocmen JS, et al.
Journal of Clinical and Experimental Investigations, 7(3), 225-251 (2016)
Daniel Vázquez-Sánchez et al.
International journal of food microbiology, 157(2), 286-296 (2012-06-19)
A total of 298 fishery products purchased from retail outlets in Galicia (NW Spain) between January 2008 and May 2009 were analyzed for the presence of Staphylococcus aureus. S. aureus was detected in a significant proportion of products (~25%). Incidence
Yuanli Liu et al.
Antimicrobial agents and chemotherapy, 56(11), 6048-6050 (2012-09-06)
Perturbation of hydroxyl radical accumulation by subinhibitory concentrations of 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed by 3 lethal antimicrobial classes. Here, we show that 2,2'-bipyridyl plus thiourea delays and/or reduces antimicrobial killing of Staphylococcus aureus by daptomycin

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