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O0146000

Olsalazine sodium

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4,4′-Dihydroxyazobenzene-3,3′-dicarboxylic acid disodium salt, 5,5′-Azobis(salicylic acid, sodium salt), Mordant Yellow 5

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About This Item

Empirical Formula (Hill Notation):
C14H8N2Na2O6
CAS Number:
6054-98-4
Molecular Weight:
346.20
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

olsalazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na+].[Na+].N(\N=C2/C=C(C(=O)C=C/2)C(=O)[O-])c1cc(c(cc1)O)C(=O)[O-]

InChI

1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,15,17H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-8-;;

InChI key

QQWFSVYVHLECFP-XBPUGJBTSA-L

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Olsalazine sodium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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[Oral therapy instead of enemas].
MMW Fortschritte der Medizin, 145(8), 56-56 (2003-03-29)
Kersti Oselin et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(9), 1452-1454 (2007-06-08)
Thiopurine S-methyltransferase (TPMT) is a biotransformation phase II enzyme responsible for the metabolic inactivation of thiopurine drugs. The present study was carried out to investigate the inhibitory potential of 15 nonsteroidal anti-inflammatory drugs (NSAIDs) on human TPMT activity in vitro.
Xinming Li et al.
Journal of the American Chemical Society, 132(50), 17707-17709 (2010-12-03)
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the
K W Schroeder
Scandinavian journal of gastroenterology. Supplement, (236)(236), 42-47 (2002-11-01)
Sulfasalazine, consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, was first used for treatment of ulcerative colitis in the early 1940s and later found effective in placebo-controlled trials for acute disease and for long-term maintenance of remission.
U Knoll et al.
Journal of veterinary pharmacology and therapeutics, 25(2), 135-143 (2002-05-10)
Olsalazine sodium (Dipentum*) has been used therapeutically against inflammatory bowel disease in human medicine as an alternative to sulphasalazine over the past 20 years. Bacteria in the colon split this prodrug into two molecules of the locally effective 5-aminosalicylic acid
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