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N7889

Supelco

Nicergoline

analytical standard, for drug analysis

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Synonym(s):
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
Empirical Formula (Hill Notation):
C24H26BrN3O3
CAS Number:
27848-84-6
Molecular Weight:
484.39
EC Number:
248-694-6
MDL number:
MFCD00869626
UNSPSC Code:
41116107
PubChem Substance ID:
329818675
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥97% (TLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

[H][C@@]12Cc3cn(C)c4cccc(c34)[C@]1(C[C@@H](COC(=O)c5cncc(Br)c5)CN2C)OC

InChI

1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

InChI key

YSEXMKHXIOCEJA-FVFQAYNVSA-N

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General description

Nicergoline is an ergot derivative, which may be used in the treatment of affective, cognitive and behavioral disorders seen in older people. It is an α -adrenergic antagonist that may be used for companion animals like cats and dogs to treat, behavioral disorders, problems with aging, excessive vocaliztion and restessness.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Cerebral and peripheral vasodilator

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maddison.EJ, et al.
Small Animal Clinical Pharmacology (2008)
Nicergoline for dementia and other age associated forms of cognitive impairment
MF and LF
Cochrane database of systematic reviews (Online), 2001-2001 null
Filippo Caraci et al.
Brain research, 1047(1), 30-37 (2005-05-11)
Nicergoline, a drug used for the treatment of Alzheimer's disease and other types of dementia, was tested for its ability to protect neurons against beta-amyloid toxicity. Pure cultures of rat cortical neurons were challenged with a toxic fragment of beta-amyloid
Jun-Sub Choi et al.
The ocular surface, 11(1), 16-18 (2013-01-17)
Many factors are involved in the corneal wound healing mechanism, including adhesion, migration, and proliferation of corneal epithelial cells. Abnormal corneal wound healing leads to corneal edema, neovascularization, scar formation, and poor vision. Three agents, 17β-estradiol, nicergoline, and β-glucan, have
Ledjan Malaj et al.
Journal of pharmaceutical sciences, 100(7), 2610-2622 (2011-01-22)
Nicergoline (NIC), a poorly water-soluble semisynthetic ergot derivative, was crystallized from several organic solvents, obtaining two different polymorphic forms, the triclinic form I and the orthorhombic form II. NIC samples were then characterized by several techniques such as (13)C cross-polarization
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